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The early retinal genes dachshund (dac), eyes absent (eya) and sine oculis (so) are key regulators of adult eye development in Drosophila. Expression data implicate homologs of all three transcription factor genes in vertebrate eye development. However, functional confirmation has thus far only been reported for so homologs. We therefore investigated(More)
The evolution of larval head morphology in holometabolous insects is characterized by reduction of antennal appendages and the visual system components. Little insight has been gained into molecular developmental changes underlying this morphological diversification. Here we compare the expression of the segment polarity gene wingless (wg) in the pregnathal(More)
Colorectal cancer is the third most common type of cancer worldwide. However, this disease can be prevented by detection and removal of precursor adenomatous polyps during optical colonoscopy (OC). During OC, the endoscopist looks for colon polyps. While hyperplastic polyps are benign lesions, adenomatous polyps are likely to become cancerous. Hence, it is(More)
The Pax6 genes eyeless (ey) and twin of eyeless (toy) are upstream regulators in the retinal determination gene network (RDGN), which instructs the formation of the adult eye primordium in Drosophila. Most animals possess a singleton Pax6 ortholog, but the dependence of eye development on Pax6 is widely conserved. A rare exception is given by the larval(More)
One of the recent innovations in computer engineering has been the development of multicore processors, which are composed of two or more independent cores in a single physical package. Today, many processors, including digital signal processors (DSPs), mobile, graphics, and general-purpose central processing units (CPUs) have a multicore design, driven by(More)
OBJECTIVE To investigate the correlation between the frequency of dawn phenomenon and obesity in patients with type 2 diabetes. METHODS This study was conducted in 98 patients with type 2 diabetes admitted to the Metabolic Disease Hospital of Tianjin Medical University from 2011 to 2014. The subjects were divided into 3 groups according to BMI: the normal(More)
Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, and an important pest of stored agricultural products. We describe its genome sequence here. This omnivorous beetle has evolved the ability to interact with a diverse chemical environment, as shown by large(More)
BACKGROUND Hepatocellular carcinoma (HCC) ranked the second among the causes of cancer mortality in China since the 1990s. Up to now, medication still plays an important role in the treatment of HCC. The therapies based on the allicin as a potential chemopreventive analog although is in its infancy at the present time, may have a significant role in the(More)
Epigallocatechin gallate (EGCG), a key active ingredient in green tea, has many anti-carcinogenic activities. The aim of the present study was to investigate whether EGCG could prevent the occurrence or metastases of orthotopic colon cancer and probe the underlined mechanisms. We observed the inhibition of EGCG on growth and metastases of colon tumor(More)