Xiaoyu Jiang

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Mapping mean axon diameter and intra-axonal volume fraction may have significant clinical potential because nerve conduction velocity is directly dependent on axon diameter, and several neurodegenerative diseases affect axons of specific sizes and alter axon counts. Diffusion-weighted MRI methods based on the pulsed gradient spin echo (PGSE) sequence have(More)
Caffeic acid possesses multiple biological effects, such as antibacterial, antioxidant, antiinflammatory, and anticancer growth; however, what effects it has on bovine mastitis have not been investigated. The aim of this study was to verify the antiinflammatory properties of caffeic acid on the inflammatory response of primary bovine mammary epithelial(More)
In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most existing technologies pursue this task as a classification problem, on a term-by-term basis, for each term in a database, such as the Gene Ontology(More)
Predicting the functional roles of proteins based on various genome-wide data, such as protein-protein association networks, has become a canonical problem in computational biology. Approaching this task as a binary classification problem, we develop a network-based extension of the spatial auto-probit model. In particular, we develop a hierarchical(More)
Mutation in the tubby gene causes adult-onset obesity, progressive retinal, and cochlear degeneration with unknown mechanism. In contrast, mutations in tubby-like protein 1 (Tulp1), whose C-terminus is highly homologous to tubby, only lead to retinal degeneration. We speculate that their diverse N-terminus may define their distinct disease profile. To(More)
We present a Monte Carlo simulation program for the propagation of polarized photons in an anisotropic scattering model consisting of poly-dispersed spherical and infinite long cylindrical scatterers. The cylinders are aligned following a Gaussian distribution. Densities and sizes of the spherical and cylindrical scatterers, as well as the orientation of(More)
The study of gene function is critical in various genomic and proteomic fields. Due to the availability of tremendous amounts of different types of protein data, integrating these datasets to predict function has become a significant opportunity in computational biology. In this paper, to predict protein function we (i) develop a novel Bayesian framework(More)
This paper puts forward a teleoperation system to control humanoid robot BHR-02 using joystick, which is convenient and simple for manipulation. This teleoperation system gives a friendly and human-based operation interface. And the system provides a switching command method for users to choose the part of the robot to operate using the joystick. Moreover(More)
PURPOSE To investigate the influence of cell membrane permeability on diffusion measurements over a broad range of diffusion times. METHODS Human myelogenous leukemia K562 cells were cultured and treated with saponin to selectively alter cell membrane permeability, resulting in a broad physiologically relevant range of 0.011-0.044 μm/ms. Apparent(More)
Amide proton transfer (APT) imaging may potentially detect mobile proteins/peptides non-invasively in vivo, but its specificity may be reduced by contamination from other confounding effects such as asymmetry of non-specific magnetization transfer (MT) effects and spin-lattice relaxation with rate R1 (=1/T1). Previously reported spillover, MT and R1(More)