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Many diseases cause significant changes to the concentrations of small molecules (a.k.a. metabolites) that appear in a person's biofluids, which means such diseases can often be readily detected from a person's " metabolic profile"—i.e., the list of concentrations of those metabolites. This information can be extracted from a biofluids Nuclear Magnetic(More)
The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and in solution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Differently from most S100 proteins, the(More)
Pre-analytical treatments of bacteria are crucial steps in bacterial metabolomics studies. In order to achieve reliable samples that can best represent the global metabolic profile in vivo both qualitatively and quantitatively, many sample treatment procedures have been developed. The use of different methods makes it difficult to compare the results among(More)
Metabolomic profiles of tissues could greatly contribute to advancements in personalized medicine but are influenced by differences in adopted preanalytical procedures; nonhomogeneous pre- and post-excision ischemia times are potential sources of variability. In this study, we monitored the impact of ischemia on the metabolic profiles, acquired with(More)
Calmodulin is a two-domain protein which in solution can adopt a variety of conformations upon reorientation of its domains. The maximum occurrence (MO) of a set of calmodulin conformations that are representative of the overall conformational space possibly sampled by the protein, has been calculated from the paramagnetism-based restraints. These(More)
In this paper, a new approach to study the effect of carrier frequency offset (CFO) due to the mismatch between the transmitter and receiver oscillators on the bit error rate (BER) performance of asynchronous multicarrier code division multiple access (MC-CDMA) systems is proposed. The closed form BER expression when the maximum ratio combining (MRC) is(More)
Data race detection becomes an important problem in GPU programming. The paper presents a novel solution mainly aimed at detecting data races happening in shared memory accesses with no use of atomic primitives. It makes use of compiler support to privatize shared data and then at run time parallelizes data race checking. It has two distinct features.(More)