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Fungi in gorgonians are now known to cause gorgonian diseases, but little attention has been paid to the nature of fungal communities associated with gorgonians. The diversity of culturable fungi associated with six species of healthy South China Sea gorgonians were investigated using a culture-dependent method followed by analysis of fungal internal(More)
BACKGROUND Micro-ribonucleic acid (miRNA)-199a-5p has been reported to be decreased in hepatocellular carcinoma (HCC) compared to normal tissue. Discoidin domain receptor-1 (DDR1) tyrosine kinase, involved in cell invasion-related signaling pathway, was predicted to be a potential target of miR-199a-5p by the use of miRNA target prediction algorithms. The(More)
The hepatitis B virus (HBV) genome forms a covalently closed circular DNA (cccDNA) minichromosome that persists in the nucleus of virus-infected hepatocytes. HBV cccDNA serves as the template for viral mRNA synthesis and is subject to epigenetic regulation by several mechanisms, including DNA methylation and histone acetylation. Recently, microRNAs(More)
Hepatitis B virus (HBV) persistence is facilitated by exhaustion of CD8 T cells that express the inhibitory receptor programmed cell death-1 (PD-1). Improvement of the HBV-specific T cell function has been obtained in vitro by inhibiting the PD-1/PD-ligand 1 (PD-L1) interaction. In this study, we examined whether in vivo blockade of the PD-1 pathway(More)
SUMMARY This paper proposes a new method that reduces the computational cost of the phase-only correlation (POC)-based methods for displacement estimation in old film sequences. Conventional POC-based methods calculate all the points of the POC and only use the highest peak of the POC and its neighboring points to estimate the displacement with subpixel(More)
We investigated the diversity of fungal communities in nine different deep-sea sediment samples of the South China Sea by culture-dependent methods followed by analysis of fungal internal transcribed spacer (ITS) sequences. Although 14 out of 27 identified species were reported in a previous study, 13 species were isolated from sediments of deep-sea(More)
To achieve a better therapeutic effect and suppress side effects for lung cancer treatments, latency involved in current radiotherapy devices is aimed to be compensated for improving accuracy of continuous (not gating) irradiation to a respiratory moving tumor. A novel prediction method of lung tumor motion is developed for compensating the latency. An(More)
BACKGROUND AIMS Our previous results showed that the knockdown of woodchuck hepatitis virus (WHV) by RNA interference (RNAi) led to upregulation of interferon stimulated genes (ISGs) in primary hepatocytes. In the present study, we tested the hypothesis that the cellular signaling pathways recognizing RNA molecules may be involved the ISG stimulation by(More)
The presence of microcalcification clusters (MCs) in mammogram is a major indicator of breast cancer. Detection of an MC is one of the key issues for breast cancer control. In this paper, we present a highly accurate method based on a morphological image processing and wavelet transform technique to detect the MCs in mammograms. The microcalcifications are(More)