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An open source project typically maintains an open bug repository so that bug reports from all over the world can be gathered. When a new bug report is submitted to the repository, a person, called a triager, examines whether it is a duplicate of an existing bug report. If it is, the triager marks it as DUPLICATE and the bug report is removed from(More)
Bug repositories are usually maintained in software projects. Testers or users submit bug reports to identify various issues with systems. Sometimes two or more bug reports correspond to the same defect. To address the problem with duplicate bug reports, a person called a triager needs to manually label these bug reports as duplicates, and link them to(More)
The phosphodiesterase type-5 (PDE5) inhibitor, sildenafil, is the first drug developed for treatment of erectile dysfunction in patients. Experimental data in animals show that sildenafil has a preconditioning-like cardioprotective effect against ischemia/reperfusion injury in the intact heart. Mechanistic studies suggest that sildenafil exerts(More)
Bug localization has attracted a lot of attention recently. Most existing methods focus on pinpointing a single statement or function call which is very likely to contain bugs. Although such methods could be very accurate, it is usually very hard for developers to understand the context of the bug, given each bug location in isolation. In this study, we(More)
—Network operators need to have a clear visibility into the applications running in their network. This is critical for both security and network management. Recent years have seen an exponential growth in the number of smart phone apps which has complicated this task. Traditional methods of traffic classification are no longer sufficient as the majority of(More)
In practice, it is common that a framework and its client programs evolve simultaneously. Thus, developers of client programs may need to migrate their programs to the new release of the framework when the framework evolves. As framework developers can hardly always guarantee backward compatibility during the evolution of a framework, migration of its(More)
Inflammatory responses are associated with blood-brain barrier (BBB) dysfunction and neurological deficits following traumatic brain injury (TBI). The aim of the present study was to investigate the effects of progesterone on the expression of the inflammatory mediators prostaglandin E2 (PGE2), cyclooxygenase-2 (COX-2), nuclear factor κB (NF-κB) and tumor(More)
BACKGROUND The authors sought to examine in-hospital and one-year outcomes of off-pump coronary artery bypass grafting (CABG) and to determine the subgroups of patients most likely to benefit from the off-pump procedure in a regular surgical practice. METHODS From March 2001 to December 2002, 1657 consecutive patients were treated with off-pump CABG and(More)
Opening of Ca2+-activated K+ (KCa) channels has been shown to confer early cardioprotection. It is unknown whether the opening of these channels also induces delayed cardioprotection. In addition, we determined the involvement of nitric oxide synthases (NOSs), which have been implicated in cardioprotection induced by opening of mitochondrial ATP-sensitive(More)
Induction of heat shock factor 1 (HSF1) is known to associate with cellular response to divergent pathophysiological stresses including whole body hyperthermia (WBH) and ischemia-reperfusion. However, a direct cause-effect relationship between HSF1 activation and cytoprotection induced by myocardial preconditioning has not been conclusively established,(More)