Xiaoyi Yang

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The human epidermal growth factor receptor 2 (HER2) receptor tyrosine kinase (RTK) oncogene is an attractive therapeutic target for the treatment of HER2-addicted tumors. Although lapatinib, an FDA-approved small-molecule HER2 and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), represents a significant therapeutic advancement in the(More)
In this paper we introduce a mixture-state document segmentation method based on wavelet and the hidden Markov tree (HMT) models. First we propose a three-state HMT segmentation method that is similar to those in the reference [1]. Then through comparing the difference weights to the three-density Gaussian mixture distribution of different textures, we find(More)
BACKGROUND Nearly ten randomized controlled trials (RCTs) of pre-exposure prophylaxis (PrEP) have been completed or are ongoing worldwide to evaluate the effectiveness of PrEP in HIV transmission among HIV-uninfected high risk populations. The purpose of this study was to evaluate the role of PrEP to prevent HIV transmission through a Mata-analysis. (More)
E2F1 is the gatekeeper of the cell cycle controlling an analogous balance between proliferation and cell death. E2F1 expression is elevated in advanced prostate cancer. However, it is still unclear that the roles and mechanisms of E2F1 on prostate cancers. Targeted knockdown by interferon RNA was applied on two prostate cancer and Hela cell lines to examine(More)
— Resistive switching memory with low switching current is critical for low-power application. In this letter, we successfully demonstrated a four-terminal resistive RAM device with ultra-low switching current. The device is SET by one pair of electrodes and RESET by the other. The rupture process of conductive filament can be resulted from electrochemical(More)
To explore the effect of placenta-derived mesenchymal stem cells on scar formation as well as the underlying mechanism. The isolated placenta-derived mesenchymal stem cells from mice were distributed in the wounded areas of scalded mouse models, attenuated inflammatory responses and decreased the deposition of collagens, thus performing a beneficial effect(More)
The Chinese national observational cohort study suggests that the treatment-as-prevention (TasP) approach can be an effective public health HIV-1 prevention strategy. However, results from that study may have been biased because the follow-up time of index patients prior to their initiation of antiretroviral therapy (ART) was excluded. In this study, we(More)
Yield and composition of pyrolysis oil were tested by fixed bed pyrolysis reactor and GC-MS. Algae pyrolysis kinetics was also calculated by Lorentzian fitting multi-heating rate method with R 2 > 0.98. Their activation energy was ranged from 94 to 216 kJ/mol and most of fitting peaks could be described by the random nucleation followed by growth mechanism.(More)
The use of recombinant human interleukin (rhIL)-15 as a potential therapeutic immune modulator and anticancer agent requires pure, stable preparations. However, purified rhIL-15 preparations readily accumulated heterogeneities. We sought to improve rhIL-15 stability through process, formulation, and targeted amino acid changes. The solution state of rhIL-15(More)