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A Global View of the Oncogenic Landscape in Nasopharyngeal Carcinoma: An Integrated Analysis at the Genetic and Expression Levels
TLDR
There is very little correlation between chromosomal copy number aberrations and expression levels of TSGs and TPGs in NPC and it is suggested that loss of the FHIT gene may be a driver of NPC tumourigenesis.
Epstein-Barr virus-encoded EBNA1 enhances RNA polymerase III-dependent EBER expression through induction of EBER-associated cellular transcription factors
TLDR
The findings reveal that EBNA1 is able to enhance EBER expression through induction of cellular transcription factors and add to the repertoire ofEBNA1's transcription-regulatory properties.
Prss37 Is Required for Male Fertility in the Mouse1
TLDR
It is demonstrated for the first time that Prss37, a previously uncharacterized putative trypsin-like serine protease, is required for male fertility and causes the absence of mature Adam3 in sperm and a defect in sperm migration from uterus into oviduct, which mainly accounts for male infertility of Prss 37-null mice.
Expression of miRNA-146a in nasopharyngeal carcinoma is upregulated by Epstein-Barr virus latent membrane protein 1.
TLDR
The expression of miRNA-146a in human nasopharyngeal carcinoma (NPC) was elevated by EBV-associated antigen LMP1, probably through the activation of the miRNAs promoter, and the levels in NPC were significantly higher than that in chronic nasopharyngitis.
GALC gene is downregulated by promoter hypermethylation in Epstein-Barr virus-associated nasopharyngeal carcinoma.
TLDR
GALC was downregulated by promoter hypermethylation and contributed to the pathogenesis of EBV-associated NPC and showed the putative tumor-suppressor effect of GALC in NPC.
Abstract PO-045: Interleukin 1 receptor accessory protein (IL1RAP) in novel targetable pathway in pancreatic cancer
TLDR
Overall, the studies indicate IL1RAP is overexpressed in PDAC, and reducing IL 1RAP and inhibiting downstream IRAK4 result in lowered tumor proliferation in vitro and in vivo, potentially via cell cycle arrest and reduced proliferative signaling.
[Expression of LMP2A, E-Cadherin and fibronectin in nasopharyngeal carcinoma and its clinical significance].
TLDR
LMP2A may promote lymph node metastasis and malignant progression of NPC by induce EMT through downregulation of E-cadherin and upregulation of fibronectin.
Expression of CMTM4 shows clinical significance in lung cancer
TLDR
It is found that CMTM4 can be used as a new marker for the treatment and prognosis of lung cancer and was associated with gender, smoking, and metastasis in lung cancer patients.
Diagnosis of Nasopharyngeal Carcinoma Using the Epstein-Barr Virus Coded Alkaline Dnase, Membrane Antigen and Thymidine Kinase
TLDR
In several Chinese populations (Southern provinces of China, Hong Kong, Taiwan, Singapore and Malaysia) the malignancy occurs with a high frequency (15–30 per 100,000 per year)(3,4).