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Effect of hyperthermic preconditioning on disruption of blood-brain barrier induced by hypoxic-ischemic insult was examined. Seven-day-old Wistar rats were separated into (1) pre-heated (15 min of hyperthermia at 41.5-42.0 degrees C) or (2) non-heated group (33 degrees C). Twenty-four hours after conditioning, all rats were subjected to 2 h hypoxia-ischemia(More)
The use of Bayesian statistics to model both general (multifamily) and specific (single-target) kinase inhibitors is investigated. The approach demonstrates an alternative to current computational methods applied to heterogeneous structure/activity data sets. This approach operates rapidly and is readily modifiable as required. A generalized model generated(More)
Expression of GDNF in developing rat brain from PND 1 to 14 and on PND 21 was examined immunocytochemically. At PND 1, intense diffuse immunoreactivity was noted within the cytoplasm of a diverse group of neuronal and nonneuronal cells, including choroid plexus epithelial cells, ependymal cells, tanycytes of the third ventricle, and cellular elements in the(More)
Ischemic/hypoxic brain damage induced in 7-day-old rats was significantly attenuated in a dose-dependent manner by intracerebral injection of glial cell line-derived neurotrophic factor (GDNF; 2 or 4 microg) within 30 min after the insult. Whereas the great majority of the vehicle-treated animals showed massive infarction involving more than 75% of the(More)
The edge-on, nearby spiral galaxy NGC 5907 has long been used as the prototype of a " noninteracting " warped galaxy. We report here the discovery of two interactions with companion dwarf galaxies that substantially change this picture. First, a faint ring structure is discovered around this galaxy that is likely due to the tidal disruption of a companion(More)
Cerebrospinal fluid concentration of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 (NT-3) was measured in normal developing rat from birth to postnatal day (PND) 21 by enzyme-linked immunosorbent assay. NGF levels were significantly higher than those of BDNF and NT-3 from PND 1-21. NGF levels decreased from PND 1-3(More)
We study the morphology and star formation properties of 159 local luminous infrared galaxy (LIRG) using multi-color images from Data Release 2 (DR2) of the Sloan Digital Sky Survey (SDSS). The LIRGs are selected from a cross-correlation analysis between the IRAS survey and SDSS. They are all brighter than 15.9 mag in the r-band and below redshift ∼ 0.1,(More)
We study the properties of hot gaseous halos in 10 nearby ultraluminous IRAS galaxies observed with the ACIS instrument on board Chandra. For all sample galaxies, diffuse soft X-ray emissions are found within ∼ 10 kpc of the central region; their spectra are well fitted by a MEKAL model plus emission lines from α-elements and other ions. The temperature of(More)
We study the properties of hot gaseous halos for 10 nearby ultraluminous IRAS galaxies observed by Chandra using the ACIS instrument. For all sample galaxies, diffuse soft X-ray emissions are found within ∼ 10 kpc of the central region; their spectra are well fit by a MEKAL model plus emission lines from α elements and other ions. The temperature of the hot(More)
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