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BACKGROUND The epidemiology of drug-induced liver injury (DILI) in China has rarely been studied before. The aim of the present study was to determine the etiology of DILI in a Chinese population by reporting a systematic analysis of the Chinese literature published from 1994 to 2011. METHODS A comprehensive database search of the Chinese literature was(More)
Icariin, a pharmacologically active component isolated from the Chinese herb Epimedium, has been shown to improve spatial learning and memory abilities in Alzheimer's disease (AD) rats through inhibition of Aβ production and tau protein hyperphosphorylation. However, the potential mechanism of icariin-induced protective effects against mitochondrial(More)
Elucidating the tumorigenic mechanism of R-2-hydroxyglutarate (R-2HG) is critical for determining how NADP(+)-IDH mutations cause cancer. Here we report that R-2HG induces cancerous metabolism and apoptosis resistance through promoting hypersuccinylation. By competitive inhibition of the mitochondrial tricarboxylic acid cycle enzyme succinate dehydrogenase(More)
A neural network predictive control method based on particle swarm optimization (PSO) for the urban expressway is proposed. A series of serial-parallel structure radial basis function neural networks are used to identify the dynamic traffic flow model of the expressway. A non-linear predictive control algorithm with the constraint conditions is presented,(More)
How to develop the software process models that satisfy the organization's standards and the characteristics of software projects, and improve it continuously, is difficulty for software organizations. A process management tool named JBPM (Jade Bird Process Management) proposes a good solution for this issue. JBPM supports component based process(More)
A lot of knowledge has been accumulated and documented in the form of process models, standards, best practices, etc. The knowledge tells how a high quality software process should look like, in other words, which constrains should be fulfilled by a software process to assure high quality software products. Compliance checking for a predefined process(More)
The present manuscript describes the development of a cell-based reporter transcriptional activation assay for evaluating induction of UGT1A1. A reporter construct (pGL-UGT1A1-Luc) encompassing the proximal promoter (nucleotide -254 to +38) and distal enhancer (-3483 to -3194) regions of the human UGT1A1 gene was generated by PCR cloning, and co-transfected(More)