Learn More
Under a tightly regulated expression mechanism, matrix metalloproteinases degrade extracellular matrix proteins and are thought to play a role in injury repair and tumor metastasis in peripheral tissues. Little is known about the function of matrix metalloproteinases or agents that regulate their production in adult brain; however, it has been shown that(More)
Glutamate-induced neurotoxicity consequent to N-methyl-D-aspartic acid (NMDA) and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid (AMPA) receptor activation underlies the pathogenesis of a wide range of central nervous system disorders, including brain ischemia. Prevention of ischemia/reperfusion (I/R)-induced neuronal injury has long been(More)
Activated macrophages produce several matrix metalloproteinases (MMPs), a family of extracellular matrix (ECM)-degrading enzymes, during wound healing and in other inflammatory states. In response to brain injury, brain microglia become "activated," in a way similar to peripheral tissue macrophages, a process which includes differentiation and probably(More)
In this paper, we present Stepping Stones and Pathways (SSP), an alternative model of building and presenting answers for the cases when queries on document collections cannot be answered just by a ranked list. Stepping Stones can handle questions like: "What is the relation of topics X and Y?" SSP addresses when the contents of a small set of related(More)
A syllabus defines the contents of a course, as well as other information such as resources and assignments. In this paper, we report on our work towards creating a syllabus repository of Computer Science courses across universities in the USA. We present some statistics from our initial collection of 8000+ syllabi. We show a syllabus creator that is(More)
Well-run screening programs for cervical cancer in the population at risk have been shown to result in a sharp decrease in the incidence and mortality of cervical cancer in a number of large populations. Expression patterns of a recently identified biomarker family, microRNA, appear to be characteristic of tumor type and developmental origin. Several tumors(More)
A course offering is a collection of learning objects composed together based on a syllabus. Syllabi define the contents of the course, as well as other information such as resources and assignments. Currently, there is no standard format for representing syllabi that can facilitate automatic processing of syllabi contents for various applications. In this(More)
Syllabi are important documents created by instructors for students. Students use syllabi to find information and to prepare for class. Instructors often need to find similar syllabi from other instructors to prepare new courses or to improve their old courses. Thus, gathering syllabi that are freely available, and creating useful services on top of the(More)
Non-homologous end-joining (NHEJ) and homologous recombination repair (HRR), contribute to repair ionizing radiation (IR)-induced DNA double-strand breaks (DSBs). Mre11 binding to DNA is the first step for activating HRR and Ku binding to DNA is the first step for initiating NHEJ. High-linear energy transfer (LET) IR (such as high energy charged particles)(More)