Xiaoxu Han

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As a well-established feature selection algorithm, principal component analysis (PCA) is often combined with the state-of-the-art classification algorithms to identify cancer molecular patterns in microarray data. However, the algorithm's global feature selection mechanism prevents it from effectively capturing the latent data structures in the(More)
BACKGROUND Co-infection with HIV-1 and HCV is a significant global public health problem and a major consideration for anti-HIV-1 treatment. HCV infection among HIV-1 positive people who are eligible for the newly launched nationwide anti-HIV-1 treatment program in China has not been well characterized. METHODOLOGY A nationwide survey of HIV-1 positive(More)
A high level of genetic diversity is a hallmark of human immu-nodeficiency virus type 1 (HIV-1). HIV-1 group M, a major (main) group of HIV-1 strains responsible for the HIV pandemic, consists of 11 subtypes and sub-subtypes have been reported to date (http://www.hiv.lanl.gov). Wide cocir-culation of and dual infection with CRF01_AE and subtype B in various(More)
BACKGROUND Natural killer (NK) cells have emerged as pivotal players in innate immunity, especially in the defense against viral infections and tumors. Killer immunoglobulin-like receptors (KIRs)--an important recognition receptor expressed on the surface of NK cells--regulate the inhibition and/or activation of NK cells after interacting with human(More)
Robust cancer molecular pattern identification from microarray data not only plays an essential role in modern clinic oncology, but also presents a challenge for statistical learning. Although principal component analysis (PCA) is a widely used feature selection algorithm in microarray analysis, its holistic mechanism prevents it from capturing the latent(More)
CD3(+)CD56(+) NKT-like cells are one of the critical effectors in the immune response to viral infection and tumors, but the functional features of NKT-like cells in HIV infection have been rarely reported. In this study, we observed and described the state of NKT-like cell functions in primary HIV-infected individuals (PHIs), chronic HIV-infected(More)