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The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China. A large-scale national survey we conducted on HIV-1 strains among MSM in 11 provinces in China from 2008 to 2013 (n = 920) identified a novel transmission cluster consisting of six strains (0.7%) that belonged to a new circulating recombinant form (designated CRF59_01B).(More)
As a well-established feature selection algorithm, principal component analysis (PCA) is often combined with the state-of-the-art classification algorithms to identify cancer molecular patterns in microarray data. However, the algorithm's global feature selection mechanism prevents it from effectively capturing the latent data structures in the(More)
BACKGROUND Co-infection with HIV-1 and HCV is a significant global public health problem and a major consideration for anti-HIV-1 treatment. HCV infection among HIV-1 positive people who are eligible for the newly launched nationwide anti-HIV-1 treatment program in China has not been well characterized. METHODOLOGY A nationwide survey of HIV-1 positive(More)
A high level of genetic diversity is a hallmark of human immu-nodeficiency virus type 1 (HIV-1). HIV-1 group M, a major (main) group of HIV-1 strains responsible for the HIV pandemic, consists of 11 subtypes and sub-subtypes have been reported to date (http://www.hiv.lanl.gov). Wide cocir-culation of and dual infection with CRF01_AE and subtype B in various(More)
BACKGROUND Natural killer (NK) cells have emerged as pivotal players in innate immunity, especially in the defense against viral infections and tumors. Killer immunoglobulin-like receptors (KIRs)--an important recognition receptor expressed on the surface of NK cells--regulate the inhibition and/or activation of NK cells after interacting with human(More)
BACKGROUND Recent studies have shown the public health importance of identifying acute HIV infection (AHI) in the men who have sex with men (MSM) of China, which has a much higher risk of HIV transmission. However, cost-utility analyses to guide policy around AHI screening are lacking. METHODOLOGY/PRINCIPAL FINDINGS An open prospective cohort was(More)
Natural killer (NK) cells are important effectors of the innate immune system that help control viral infections and tumorigenesis. However, the relationship between NK cell function and HIV disease progression remains poorly defined. In this study, we examined the function of NK cells in Chinese patients who were HIV-infected but treatment-naïve. These(More)
OBJECTIVE To examine the distribution of HIV-1 genotypes among injecting drug users (IDUs) from Dehong, Yunnan province. MATERIALS AND METHODS Blood samples from a total of 95 HIV-positive IDUs were retrospectively analyzed. Samples were collected between 2005 and 2009 from four cities in Dehong prefecture, western Yunnan province, the geographical origin(More)