• Publications
  • Influence
Sulfolobus tengchongensis Spindle-Shaped Virus STSV1: Virus-Host Interactions and Genomic Features
TLDR
Both morphological and genomic features identify STSV1 as a novel virus infecting the genus Sulfolobus, which has the morphology of a spindle with a tail of variable length and is the largest of the known spindle-shaped viruses. Expand
Atomic model of a cypovirus built from cryo-EM structure provides insight into the mechanism of mRNA capping
TLDR
The structure shows that the enzymatic domains of the pentameric turret of CPV are topologically conserved and that there are five unique channels connecting the guanylyltransferase and methyltransferase regions. Expand
Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site
TLDR
The data show for the first time that strain-specific holes in the glycan fence can allow the development of tier 2 neutralizing antibodies to native spikes, and cross-neutralization can occur in the absence of protecting glycan. Expand
A novel single-tailed fusiform Sulfolobus virus STSV2 infecting model Sulfolobus species
TLDR
The single-tailed fusiform virus STSV2 can be stably cultured over long periods in laboratory strains of Sulfolobus and no evidence was found for cell lysis under different stress conditions, therefore, it constitutes an excellent model virus for archaeal virus–host studies. Expand
HIV-1 Virus-Like Particles Produced by Stably Transfected Drosophila S2 Cells: a Desirable Vaccine Component
TLDR
HIV-1 VLP produced by the S2 expression system has many desirable features to be developed into a vaccine component against HIV-1, including ELISA-binding, neutralizing, antibody-dependent cell-mediated cytotoxicity and antibody-mediated viral inhibition. Expand
Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine: Vaccinia Tiantan Strain
TLDR
The immunogenicity profile of a replication-competent smallpox vaccine (vaccinia Tiantan, VTT strain) for inducing neutralizing antibodies (Nabs) through mucosal vaccination, which is noninvasive and has a critical implication for massive vaccination programs, is studied for the first time. Expand
The novel bis-benzylisoquinoline PY35 reverses P-glycoprotein-mediated multidrug resistance.
TLDR
Investigation of the ability of PY35 to reverse P-gp-mediated MDR and its mechanism in resistant K562/Adriamycin (ADM), MCF-7/ADM cells and their sensitive cell lines showed that PY 35 can reverse MDR more effectively than the drug prototype‑Tet, and may be a potential inhibitor to overcome drug resistance. Expand
Biodegradation and Toxicity of Protease/Redox/pH Stimuli-Responsive PEGlated PMAA Nanohydrogels for Targeting Drug delivery.
TLDR
The experimental results showed that the PEG modification could greatly enhance the long in vivo circulation lifetime and reduce the acute toxicity of the nanohydrogels, and the in vitro experiment results indicated that the multidrug-loaded system had synergistic effect on cancer therapy. Expand
A Novel Replication-Competent Vaccinia Vector MVTT Is Superior to MVA for Inducing High Levels of Neutralizing Antibody via Mucosal Vaccination
TLDR
A head-to-head comparison of two viral vectors modified vaccinia Ankara (MVA) and a novel replication-competent modified Vaccinia Tian Tan (MVTT) for inducing neutralizing antibodies (Nabs) via intramuscular and mucosal vaccinations in mice finds MVTT is an attractive live viral vector for mucosal vaccination. Expand
Cryo-EM structures of two bovine adenovirus type 3 intermediates.
TLDR
Near-atomic structures of two bovine Ad type 3 (BAd3) intermediates obtained by cryo-electron microscopy suggest that cleavage of precursor protein VI occurs during, rather than after, the DNA encapsidation process, and provide insights into the mechanism of Ad assembly. Expand
...
1
2
3
...