Xiaoxia Yang

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The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent ubiquitination and proteolysis of I kappa B alpha, which then releases NF-kappa B to promote gene transcription. The multisubunit I kappa B kinase responsible for this phosphorylation contains two catalytic subunits, termed I kappa B kinase(More)
Herbs are often administered in combination with therapeutic drugs, raising the potential of herb-drug interactions. An extensive review of the literature identified reported herb-drug interactions with clinical significance, many of which are from case reports and limited clinical observations. Cases have been published reporting enhanced anticoagulation(More)
PURPOSE Multiple myeloma (MM) is an incurable plasma-cell neoplasm for which most treatments involve a therapeutic agent combined with dexamethasone. The preclinical combination of lenalidomide with the mTOR inhibitor CCI-779 has displayed synergy in vitro and represents a novel combination in MM. PATIENTS AND METHODS A phase I clinical trial was(More)
A new approach is presented to extract more robust affine invariant features for image matching. The novelty of our approach is a hierarchical filtering strategy for affine invariant feature detection, which is based on information entropy and spatial dispersion quality constraints. The concept of spatial dispersion quality is introduced to quantify the(More)
Dynamic changes of myocardial fiber and sheet structure are key determinants of regional ventricular function. However, quantitative characterization of the contraction-related changes in fiber and sheet structure has not been reported. The objective of this study was to quantify cardiac fiber and sheet structure at selected phases of the cardiac cycle.(More)
Nonreceptor protein tyrosine kinases including Lck, ZAP-70, and Itk play essential roles in T-cell receptor (TCR) signaling. Gene knockout studies have revealed that mice lacking these individual kinases exhibit various degrees of immunodeficiency; however, highly selective small molecule inhibitors of these kinases as potential immunosuppressive agents(More)
The objective of this work was to characterize the preclinical pharmacokinetics, tissue distribution, and excretion profiles of recombinant human parathyroid hormone (1-34) [rhPTH (1-34)] in healthy rats. Pharmacokinetic properties of (125)I-rhPTH (1-34) were examined after a single subcutaneous (s.c.) and intravenous (i.v.) bolus injection, respectively.(More)
MRI has recently been used for noninvasive examination of retinal structure and function in rats and cats. However, the advantages of quantitative high-resolution MRI of retina from mice have not yet been explored. In the present study, T(1) and T(2) relaxation time constants and the directional apparent diffusion coefficient (ADC) in the retina of C57/BL6(More)
The responses of enzymatic biomarkers of earthworms Eisenia fetida to low-level exposures of cadmium (Cd) (2.50mg kg(-1)), pyrene (0.96mg kg(-1)) or their combination were investigated in this study. A set of enzymatic biomarkers, namely, cytochrome P450 (CYP) as a family of phase I enzymes, glutathione-s-transferase (GST) as one of phase II enzymes and(More)
Extensive first-pass metabolism of ingested bisphenol A (BPA) in the gastro-intestinal tract and liver restricts blood concentrations of bioactive BPA to <1% of total BPA in humans and non-human primates. Absorption of ingested BPA through non-metabolizing tissues of the oral cavity, recently demonstrated in dogs, could lead to the higher serum BPA(More)