Xiaowen Chen

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MicroRNAs (miRNAs) are non-coding RNAs that play important roles in post-transcriptional regulation. Identification of miRNAs is crucial to understanding their biological mechanism. Recently, machine-learning approaches have been employed to predict miRNA precursors (pre-miRNAs). However, features used are divergent and consequently induce different(More)
Supporting Distributed Shared Memory (DSM) is essential for multi-core Network-on-Chips for the sake of reusing huge amount of legacy code and easy programmability. We propose a microcoded controller as a hardware module in each node to connect the core, the local memory and the network. The controller is programmable where the DSM functions such as(More)
The investigation of topological properties of proteins in protein-protein interaction network (PPIN) has great potentials to identify basic protein functions and mechanisms of action. Based on human PPIN, previous study has shown that the topological properties of drug targets are significantly distinguished from those of proteins that are not targeted by(More)
Autohydrolysis using water is a promising method to extract hemicelluloses from wood prior to pulping in order to make co-products such as ethanol and acetic acid besides pulp. Many studies have been carried out on the kinetics and mechanism of autohydrolysis using batch reactors. The present study was performed in a continuous mixed flow reactor where the(More)
The effect of mechanical refining on the enzymatic digestibility of pretreated corn stover (PCS) was investigated. Low severity, dilute sulfuric acid PCS was subjected to mechanical refining using a bench-scale food processor blender, a PFI mill, a 12-inch laboratory disk refiner, and a 25 mm co-rotating twin-screw extruder. Glucose yields from enzymatic(More)
The emergence of large-scale chip multicore processors makes the on-chip parallel H.264/AVC encoder with high parallelism feasible. To reduce the data reload frequency, a hierarchical chip multi-core DSP platform with overall 64 DSP cores is designed to accommodate the computation/data-intensive H.264/AVC encoder. To increase parallelism, macro block level(More)
The identification of genes that predict in vitro cellular chemosensitivity of cancer cells is of great importance. Chemosensitivity related genes (CRGs) have been widely utilized to guide clinical and cancer chemotherapy decisions. In addition, CRGs potentially share functional characteristics and network features in protein interaction networks (PPIN). In(More)
Transgenic corn producing Cry1Ac toxins from Bacillus thuringiensis (Bt) provides effective control of Asian corn borer, Ostrinia furnacalis (Guenée), and thus reduces insecticide applications. However, whether Bt corn exerts undesirable effects on non-target arthropods (NTAs) is still controversial. We conducted a 2-yr study in Shangzhuang Agricultural(More)
MOTIVATION Alzheimer's disease (AD) is a severe neurodegenerative disease of the central nervous system that may be caused by perturbation of regulatory pathways rather than the dysfunction of a single gene. However, the pathology of AD has yet to be fully elucidated. RESULTS In this study, we systematically analyzed AD-related mRNA and miRNA expression(More)
The sex determination for zebrafish is controlled by a combination of genetic and environmental factors. The determination of sex in zebrafish has been suggested to rely on a mechanism that is affected by germ cell-derived signals. To begin our current study, a simplified and efficient germ cell-specific promoter of the dead end (dnd) gene was identified.(More)