Xiaowei Zhong

Learn More
Augmented reality is a variation of virtual reality. It allows the user to see computer generated virtual objects superimposed upon the real world through the use of some kind of see-through head-mounted display. Human users of such system can interact with the virtual world and have additional information, such as character description of physical objects(More)
Recently significant advances have been witnessed in the area of distributed word representations based on neural networks, which are also known as word embeddings. Among the new word embedding models, skip-gram negative sampling (SGNS) in the word2vec toolbox has attracted much attention due to its simplicity and effectiveness. However , the principles of(More)
Recently, solving rank minimization problems by leverag-ing nonconvex relaxations has received significant attention. Some theoretical analyses demonstrate that it can provide a better approximation of original problems than convex re-laxations. However, designing an effective algorithm to solve nonconvex optimization problems remains a big challenge. In(More)
The N-terminal region of both skeletal and cardiac ryanodine receptor is a disease mutation hotspot. Recently, a crystal structure of the RyR1 fragment (residues 1-559) was solved. This N-terminal structure contains three separate domains, A, B, and C, and was docked into a central vestibule in a full-length RyR1 cryo-EM map. Here, we reconstructed(More)
Ryanodine receptors (RyRs) form a class of intracellular calcium release channels in various excitable tissues and cells such as muscles and neurons. They are the major cellular mediators of the release of calcium ions from the sarcoplasmic reticulum, an essential step in muscle excitation-contraction coupling. Several crystal structures of skeletal muscle(More)
Asynchronous parallel optimization algorithms for solving large-scale machine learning problems have drawn significant attention from academia to industry recently. This paper proposes a novel algorithm, decoupled asynchronous proximal stochastic gradient descent (DAP-SGD), to minimize an objective function that is the composite of the average of multiple(More)
Calmodulin (CaM), a 16 kDa ubiquitous calcium-sensing protein, is known to bind tightly to the calcium release channel/ryanodine receptor (RyR), and modulate RyR function. CaM binding studies using RyR fragments or synthetic peptides have revealed the presence of multiple, potential CaM-binding regions in the primary sequence of RyR. In the present study,(More)
  • 1