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While many public cloud providers offer pay-as-you-go computing, their varying approaches to infrastructure, virtualization, and software services lead to a problem of plenty. To help customers pick a cloud that fits their needs, we develop CloudCmp, a systematic comparator of the performance and cost of cloud providers. CloudCmp measures the elastic(More)
Users increasingly rely on the trustworthiness of the information exposed on Online Social Networks (OSNs). In addition, OSN providers base their business models on the marketability of this information. However, OSNs suffer from abuse in the form of the creation of fake accounts, which do not correspond to real humans. Fakes can introduce spam, manipulate(More)
In today's Internet, users can choose their local Internet service providers (ISPs), but once their packets have entered the network, they have little control over the overall routes their packets take. Giving a user the ability to choose between provider-level routes has the potential of fostering ISP competition to offer enhanced service and improving(More)
This paper presents the design of a new Internet routing architecture (NIRA). In today's Internet, users can pick their own ISPs, but once the packets have entered the network, the users have no control over the overall routes their packets take. NIRA aims at providing end users the ability to choose the sequence of Internet service providers a packet(More)
To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the control of endogenous htt regulatory machinery on the BAC. BACHD mice(More)
Tobacco-related diseases such as lung cancer cause over 4.2 million deaths annually, with approximately 400,000 deaths per year occurring in the US. Genotoxic effects of tobacco components have been described, but effects on signaling pathways in normal cells have not been described. Here, we show activation of the serine/threonine kinase Akt in(More)
A major challenge in systems neuroscience is to perform precise molecular genetic analyses of a single neuronal population in the context of the complex mammalian brain. Existing technologies for profiling cell type-specific gene expression are largely limited to immature or morphologically identifiable neurons. In this study, we developed a simple method(More)