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While many public cloud providers offer pay-as-you-go computing, their varying approaches to infrastructure, virtualization, and software services lead to a problem of plenty. To help customers pick a cloud that fits their needs, we develop CloudCmp, a systematic comparator of the performance and cost of cloud providers. CloudCmp measures the elastic(More)
Users increasingly rely on the trustworthiness of the information exposed on Online Social Networks (OSNs). In addition, OSN providers base their business models on the marketability of this information. However, OSNs suffer from abuse in the form of the creation of fake accounts , which do not correspond to real humans. Fakes can introduce spam, manipulate(More)
— The Thorup-Zwick (TZ) compact routing scheme is the first generic stretch-3 routing scheme delivering a nearly optimal per-node memory upper bound. Using both direct analysis and simulation, we derive the stretch distribution of this routing scheme on Internet-like interdomain topologies. By investigating the TZ scheme on random graphs with power-law node(More)
To elucidate the pathogenic mechanisms in Huntington's disease (HD) elicited by expression of full-length human mutant huntingtin (fl-mhtt), a bacterial artificial chromosome (BAC)-mediated transgenic mouse model (BACHD) was developed expressing fl-mhtt with 97 glutamine repeats under the control of endogenous htt regulatory machinery on the BAC. BACHD mice(More)
The spatiotemporal activities of astrocyte Ca²⁺ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca²⁺ and glutamate indicators as well as pharmacogenetic and electrical control of neurotransmitter release to explore astrocyte activity in the hippocampal mossy fiber pathway. Our data revealed numerous localized, spontaneous(More)
We present the design of a routing system in which end-systems set tags to select non-shortest path routes as an alternative to explicit source routes. Routers collectively generate these routes by using tags as hints to independently deflect packets to neighbors that lie off the shortest-path. We show how this can be done simply, by local extensions of the(More)
This paper presents the design and implementation of a filter-based DoS defense system (StopIt) and a comparison study on the effectiveness of filters and capabilities. Central to the StopIt design is a novel closed-control, open-service architecture: any receiver can use StopIt to block the undesired traffic it receives, yet the design is robust to various(More)
In today's Internet, users can choose their local Internet service providers (ISPs), but once their packets have entered the network, they have little control over the overall routes their packets take. Giving a user the ability to choose between provider-level routes has the potential of fostering ISP competition to offer enhanced service and improving(More)