Learn More
BACKGROUND There is no single generally accepted clinical definition of frailty. Previously developed tools to assess frailty that have been shown to be predictive of death or need for entry into an institutional facility have not gained acceptance among practising clinicians. We aimed to develop a tool that would be both predictive and easy to use. (More)
OBJECTIVES To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples. DESIGN Cross-sectional and cohort studies. SETTING Seven population-based and four clinical/institutional surveys in four developed(More)
OBJECTIVES To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes. DESIGN Retrospective cohort studies. SETTING Two population-based studies of people aged approximately 70 at baseline and followed up to 10 years (in the Canadian Study of Health and Aging(More)
OBJECTIVES To evaluate the prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. DESIGN Prospective cohort study. SETTING The National Population Health Survey of Canada, with frailty estimated at baseline (1994/95) and mortality follow-up to 2004/05. PARTICIPANTS Community-dwelling older adults (N=2,740,(More)
BACKGROUND AND PURPOSE There is a need for empirical studies to define criteria for vascular cognitive impairment (VCI) subtypes. In this paper, we report the predictive validity of a subtype classification scheme based on clinical and radiographic features. METHODS Nine Canadian memory clinics participated in the Consortium to Investigate Vascular(More)
BACKGROUND The prevalence of frailty increases with age in older adults, but frailty is largely unreported for younger adults, where its associated risk is less clear. Furthermore, less is known about how frailty changes over time among younger adults. We estimated the prevalence and outcomes of frailty, in relation to accumulation of deficits, across the(More)
Recent research has demonstrated that brain circulation abnormalities, either during task-induced neural activity or at rest, are more commonly associated with Alzheimer's disease (AD) than was previously thought. This is consistent with the increasing attention to the early involvement of vascular risk factors in the development of AD, in addition to the(More)
BACKGROUND AND PURPOSE The importance of executive dysfunction is increasingly recognized in the dementia syndrome. Although executive dysfunction has been associated with subcortical ischemic lesions, it may not be unique to VCI or to its clinical subtypes. METHODS Secondary analysis of the CIVIC study, a multi-centre memory clinic cohort study. An(More)
The health of individuals is highly heterogeneous, as is the rate at which they age. To account for such heterogeneity, we have suggested that an individual’s health status can be represented by the number of health deficits (broadly defined by biological and clinical characteristics) that they accumulate. This allows health to be expressed in a single(More)
BACKGROUND it has been observed that a frailty index (FI) is limited by the value of 0.7. Whether this holds in countries with higher mortality rates is not known. OBJECTIVES to test for and quantify a limit in very old Chinese adults and to relate mortality risk to the FI. DESIGN secondary analysis of four waves (1998, 2000, 2002 and 2005) of the(More)