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BACKGROUND There is no single generally accepted clinical definition of frailty. Previously developed tools to assess frailty that have been shown to be predictive of death or need for entry into an institutional facility have not gained acceptance among practising clinicians. We aimed to develop a tool that would be both predictive and easy to use. (More)
OBJECTIVES To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples. DESIGN Cross-sectional and cohort studies. SETTING Seven population-based and four clinical/institutional surveys in four developed(More)
BACKGROUND The prevalence of frailty increases with age in older adults, but frailty is largely unreported for younger adults, where its associated risk is less clear. Furthermore, less is known about how frailty changes over time among younger adults. We estimated the prevalence and outcomes of frailty, in relation to accumulation of deficits, across the(More)
OBJECTIVES To construct and validate a frailty index (FI) that is clinically sensible and practical for geriatricians by basing it on a routinely used comprehensive geriatric assessment (CGA) instrument. DESIGN Secondary analysis of a 3-month randomized, controlled trial of a specialized mobile geriatric assessment team. SETTING Rural Nova Scotia.(More)
OBJECTIVES To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes. DESIGN Retrospective cohort studies. SETTING Two population-based studies of people aged approximately 70 at baseline and followed up to 10 years (in the Canadian Study of Health and Aging(More)
OBJECTIVES To evaluate the prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. DESIGN Prospective cohort study. SETTING The National Population Health Survey of Canada, with frailty estimated at baseline (1994/95) and mortality follow-up to 2004/05. PARTICIPANTS Community-dwelling older adults (N=2,740,(More)
BACKGROUND AND AIMS Objectives were to develop a frailty index (FI) based on a standard comprehensive geriatric assessment (CGA) derived from a clinical examination; to assess the validity of the FI-CGA and to compare its precision with other frailty measures. METHODS DESIGN Secondary analysis of a prospective cohort study, with five-year follow-up(More)
Recent research has demonstrated that brain circulation abnormalities, either during task-induced neural activity or at rest, are more commonly associated with Alzheimer's disease (AD) than was previously thought. This is consistent with the increasing attention to the early involvement of vascular risk factors in the development of AD, in addition to the(More)
BACKGROUND Frailty in individuals can be operationalized as the accumulation of health deficits, for which several trends have been observed in Western countries. Less is known about deficit accumulation in China, the country with the world's largest number of older adults. METHODS This study analyzed data from the Beijing Longitudinal Study of Aging, to(More)
BACKGROUND Although cholinesterase inhibitors have produced statistically significant treatment effects, their clinical meaningfulness in Alzheimer's disease is disputed. An important aspect of clinical meaningfulness is the extent to which an intervention meets the goals of treatment. METHODS In this randomized controlled trial, patients with mild to(More)