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BACKGROUND There is no single generally accepted clinical definition of frailty. Previously developed tools to assess frailty that have been shown to be predictive of death or need for entry into an institutional facility have not gained acceptance among practising clinicians. We aimed to develop a tool that would be both predictive and easy to use. (More)
BACKGROUND While on average health declines with age, it also becomes more variable with age. As a consequence of this marked variability, it becomes more important as people age to have a means of summarizing health status, but how precisely to do so remains controversial. We developed one measure of health status, personal biological age, from a frailty(More)
OBJECTIVES To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples. DESIGN Cross-sectional and cohort studies. SETTING Seven population-based and four clinical/institutional surveys in four developed(More)
OBJECTIVES To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes. DESIGN Retrospective cohort studies. SETTING Two population-based studies of people aged approximately 70 at baseline and followed up to 10 years (in the Canadian Study of Health and Aging(More)
Several machine learning techniques (multilayer and single layer perceptron, logistic regression, least square linear separation and support vector machines) are applied to calculate the risk of death from two biomedical data sets, one from patient care records, and another from a population survey. Each dataset contained multiple sources of information:(More)
The health of individuals is highly heterogeneous, as is the rate at which they age. To account for such heterogeneity, we have suggested that an individual’s health status can be represented by the number of health deficits (broadly defined by biological and clinical characteristics) that they accumulate. This allows health to be expressed in a single(More)
OBJECTIVES To evaluate the potential of an artificial neural network (ANN) in predicting survival in elderly Canadians, using self-report data. DESIGN Cohort study with up to 72 months follow-up. SETTING Forty self-reported characteristics were obtained from the community sample of the Canadian Study of Health and Aging. An individual frailty index(More)
In a prospective multi-panel cohort study, we investigated how, from late middle age, individuals' health status improves or declines. In the Canadian National Population Health Survey, transition probabilities between different health states were estimated for 4330 people (58.8% women) aged 55+ at baseline over 2-year intervals from 1994 to 2000. Health(More)
BACKGROUND On average, cognition declines as people age, but improvement can also occur. OBJECTIVE To evaluate the dynamics of age-related changes in brain structure and cognitive function in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) and in healthy control (HC) older adults. METHODS High-resolution 3-Tesla MRI and(More)
Recent research has demonstrated that brain circulation abnormalities, either during task-induced neural activity or at rest, are more commonly associated with Alzheimer's disease (AD) than was previously thought. This is consistent with the increasing attention to the early involvement of vascular risk factors in the development of AD, in addition to the(More)