Learn More
BACKGROUND There is no single generally accepted clinical definition of frailty. Previously developed tools to assess frailty that have been shown to be predictive of death or need for entry into an institutional facility have not gained acceptance among practising clinicians. We aimed to develop a tool that would be both predictive and easy to use. (More)
OBJECTIVES To evaluate the prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation. DESIGN Prospective cohort study. SETTING The National Population Health Survey of Canada, with frailty estimated at baseline (1994/95) and mortality follow-up to 2004/05. PARTICIPANTS Community-dwelling older adults (N=2,740,(More)
OBJECTIVES To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes. DESIGN Retrospective cohort studies. SETTING Two population-based studies of people aged approximately 70 at baseline and followed up to 10 years (in the Canadian Study of Health and Aging(More)
OBJECTIVES To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples. DESIGN Cross-sectional and cohort studies. SETTING Seven population-based and four clinical/institutional surveys in four developed(More)
BACKGROUND The prevalence of frailty increases with age in older adults, but frailty is largely unreported for younger adults, where its associated risk is less clear. Furthermore, less is known about how frailty changes over time among younger adults. We estimated the prevalence and outcomes of frailty, in relation to accumulation of deficits, across the(More)
BACKGROUND it has been observed that a frailty index (FI) is limited by the value of 0.7. Whether this holds in countries with higher mortality rates is not known. OBJECTIVES to test for and quantify a limit in very old Chinese adults and to relate mortality risk to the FI. DESIGN secondary analysis of four waves (1998, 2000, 2002 and 2005) of the(More)
BACKGROUND Smoking is common in China, where the population is aging rapidly. This study evaluated the relationship between smoking and frailty and their joint association with health and survival in older Chinese men and women. METHODS Data came from the Beijing Longitudinal Study of Aging, a representative cohort study with a 15-year follow-up.(More)
Recent research has demonstrated that brain circulation abnormalities, either during task-induced neural activity or at rest, are more commonly associated with Alzheimer's disease (AD) than was previously thought. This is consistent with the increasing attention to the early involvement of vascular risk factors in the development of AD, in addition to the(More)
Alzheimer's disease (AD) affects several important molecules in brain metabolism. The resulting neurochemical changes can be quantified non-invasively in localized brain regions using in vivo single-voxel proton magnetic resonance spectroscopy (SV 1H MRS). Although the often heralded diagnostic potential of MRS in AD largely remains unfulfilled, more recent(More)
OBJECTIVES To construct and validate a frailty index (FI) that is clinically sensible and practical for geriatricians by basing it on a routinely used comprehensive geriatric assessment (CGA) instrument. DESIGN Secondary analysis of a 3-month randomized, controlled trial of a specialized mobile geriatric assessment team. SETTING Rural Nova Scotia.(More)