Xiaoting Yang

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Kinetic rate laws Following our previous analysis 19,26 , the generation of fibril mass, M, when both primary and secondary nucleation events occur is described by the integrated rate law: í µí±€(í µí±¡) í µí±€(∞) = 1 − � í µí°µ + + í µí° ¶ + í µí°µ + + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + � í µí±˜ ∞ 2(More)
Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present an approach to investigate these factors through acquisition of highly reproducible data and global kinetic analysis to determine the mechanistic influence of intrinsic and(More)
— Most small robots require a tethered connection with a power and control source. The tether has advantages, namely robust communication and safe recovery, and disadvantages, tangling with obstacles and rough terrain. Active tether is a new research area for tethered robot systems. It provides continuously distributed form of actuation for robots that(More)
—Cooperative transmission protocols are always designed to reach the largest diversity gain and the largest network capacity simultaneously. The concept of diversity-multiplexing tradeoff (DMT) in MIMO systems put forward by Zheng and Tse has been extended to this field. In fact, many works that follow from this famous rule have been done to achieve more(More)
Ziziphus is an important genus within the family Rhamnaceae. This genus includes several important fruit tree species that are widely planted in China and India, such as the Chinese jujube (Ziziphus jujuba Mill.), the wild jujube (Z. acidojujuba), and the Indian jujube (Z. mauritiana). However, information about their domestication based on the chlorotype(More)
Computational Polymers (SCP) is a concept of layered class of active material that can sense its environment and, due to its cognitive capabilities, react " intelligently " to those changes. In such a material, we envision semiconducting polymer based sensing, actuation, and information processing for on-board decision making to be combined into one active(More)
—This paper discusses two components suitable for construction of an all-polymer robot, namely a Synthetic Neural Network and water hammer based actuation. A new data processing element, termed Synthetic Neural Network, or SNN, based on a concept of a polymer-based bistable memory device and a conventional transistor made from polymers, is proposed. A(More)
The amyloid β peptide (Aβ42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. Aβ42 has a net negative charge at physiological pH and modulations of intermolecular electrostatic interactions can significantly alter its aggregation behaviour. Variations in sequence and solution(More)
Alzheimer's disease is an increasingly prevalent neurodegenerative disorder whose pathogenesis has been associated with aggregation of the amyloid-β peptide (Aβ42). Recent studies have revealed that once Aβ42 fibrils are generated, their surfaces strongly catalyse the formation of neurotoxic oligomers. Here we show that a molecular chaperone, a Brichos(More)