Xiaoting Yang

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Kinetic rate laws Following our previous analysis 19,26 , the generation of fibril mass, M, when both primary and secondary nucleation events occur is described by the integrated rate law: í µí±€(í µí±¡) í µí±€(∞) = 1 − � í µí°µ + + í µí° ¶ + í µí°µ + + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + í µí±’ í µí¼…í µí¼… í µí°µ − + í µí° ¶ + � í µí±˜ ∞ 2(More)
Disease related mutations and environmental factors are key determinants of the aggregation mechanism of the amyloid-β peptide implicated in Alzheimer's disease. Here we present an approach to investigate these factors through acquisition of highly reproducible data and global kinetic analysis to determine the mechanistic influence of intrinsic and(More)
Ziziphus is an important genus within the family Rhamnaceae. This genus includes several important fruit tree species that are widely planted in China and India, such as the Chinese jujube (Ziziphus jujuba Mill.), the wild jujube (Z. acidojujuba), and the Indian jujube (Z. mauritiana). However, information about their domestication based on the chlorotype(More)
The amyloid β peptide (Aβ42), whose aggregation is associated with Alzheimer's disease, is an amphiphatic peptide with a high propensity to self-assemble. Aβ42 has a net negative charge at physiological pH and modulations of intermolecular electrostatic interactions can significantly alter its aggregation behaviour. Variations in sequence and solution(More)
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