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TR-FRET Assays of Huntingtin Protein Fragments Reveal Temperature and PolyQ Length-Dependent Conformational Changes
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) technology is a widely used immunoassay that enables high-throughput quantitative measurements of proteins of interest. One of the wellExpand
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with anExpand
A high-throughput-compatible assay to measure the degradation of endogenous Huntingtin proteins
  • Peng Wu, M. Lu, +5 authors B. Lu
  • Biology, Medicine
  • Acta Pharmacologica Sinica
  • 6 June 2016
Aim:The accumulation of disease-causing proteins is a common hallmark of many neurodegenerative disorders. Measuring the degradation of such proteins using high-throughput-compatible assays is highlyExpand
Algorithm of PFE and Its Application in Shenzhen Urban Transport Simulation System
This paper introduces the OD matrix adjustment, especially the development and application for PFE. In the second part, the logical structure and core module algorithms are deeply analyzed andExpand
Study of the Parking Guidance Reliability of Urban Parking Variable Message Signs
Reliability is a key factor in ensuring the benefits of urban parking message signs. First, this paper seeks to define the reliability of parking guidance provided by urban parking variable messageExpand
Analysis about Business Investing and Financing Models of Urban Rail Transit
The rapid development of rail transit inevitably needs large capital investments. As a huge investment in urban infrastructure projects, financing is the key to the implementation of theExpand