Xiaotao Chen

Learn More
Understanding stage-dependent oncogenic mechanisms is critical to develop not only targeted therapies, but also diagnostic markers and preventive strategies. The mechanisms acting during cancer initiation remain elusive, largely owing to a lack of suitable animal models and limited availability of human precancerous lesions. Here we show using genetic mouse(More)
Power consumption is an important factor in chip design. The fundamental design decisions drawn during early design space exploration at electronic system level (ESL) have a large impact on the power consumption. This requires to estimate power already at ESL, which is usually not possible using standard ESL component libraries due to missing power models.(More)
Complex many-core architectures are seen as the solution to tackle the computational workloads of the next years. To find the best trade-off between power and performance, different processor architectures have to be considered and evaluated in a thorough and power-aware design space exploration. This is highly facilitated by electronic system level (ESL)(More)
Diagnosing performance violations is one of the biggest challenges in transaction level modeling of systems. In this paper, we propose a methodology to localize root causes of latency or throughput violations. We present a concurrent pattern mining approach to infer frequent patterns from transaction traces to localize root causes. We apply three categories(More)
Hepatocellular carcinoma (HCC) cell lines are useful in vitro models for the study of primary HCCs. Because cell lines acquire additional mutations in culture, it is important to understand to what extent HCC cell lines retain the genetic landscapes of primary HCCs. Most HCC cell lines were established during the last century, precluding comparison between(More)
UNLABELLED Hepatocellular carcinoma (HCC) is a cancer lacking effective therapies. Several measures have been proposed to treat HCCs, such as senescence induction, mitotic inhibition, and cell death promotion. However, data from other cancers suggest that single use of these approaches may not be effective. Here, by genetic targeting of Survivin, an(More)
internet is one of the most promising future energy infrastructures which could enhance energy efficiency and improve system operating flexibility. In analog to the micro-grid, micro energy internet puts more emphasis on distribution level and consumer side. The concept and design principles of smart micro energy internet are proposed to accommodate(More)
Hereditary tyrosinemia type I (HT1) is caused by a deficiency in the enzyme fumarylacetoacetate hydrolase (Fah). Fah-deficient mice and pigs are phenotypically analogous to human HT1, but do not recapitulate all the chronic features of the human disorder, especially liver fibrosis and cirrhosis. Rats as an important model organism for biomedical research(More)