Xiaosong Dong

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Growing evidence supports the hypothesis that narcolepsy with cataplexy is an autoimmune disease. We here report genome-wide association analyses for narcolepsy with replication and fine mapping across three ethnic groups (3,406 individuals of European ancestry, 2,414 Asians and 302 African Americans). We identify a SNP in the 3' untranslated region of(More)
To investigate the effect of uvlopalatopharyngoplasty (UPPP) on post-surgery continuous positive airway pressure (CPAP) treatment during sleep in patients with obstructive sleep apnea–hypopnea syndrome (OSAHS). Thirty-one OSAHS patients after UPPP surgery were recruited and studied on for more than 12 months after the procedure. Among them, 24 patients were(More)
The aim was to evaluate the inter-rater reliability in scoring sleep stages in two sleep labs in Berlin Germany and Beijing China. The subjects consist of polysomnography (PSGs) from 15 subjects in a German sleep laboratory, with 7 mild to moderate sleep apnea hypopnea syndrome (SAHS) patients and 8 healthy controls, and PSGs from 15 narcolepsy patients in(More)
OBJECTIVE To investigate the compliance with nasal continuous positive airway pressure (nCPAP) therapy in patients with sleep apnea syndrome (SAS) and to analyze the factors influencing the compliance. METHODS A questionnaire about compliance was sent to 118 patients with SAS who accepted nCPAP home therapy from Feb, 1994 to Aug, 2000. The factors(More)
We report a 5-year-old boy with epilepsy and narcolepsy-cataplexy. He developed myoclonic seizures at the age of 4 years, which manifested as head shaking to the left. Approximately 6 months later, narcolepsy-cataplexy with excessive daytime sleepiness occurred. Although a short-time electroencephalography (EEG) and 24-hour ambulatory EEG monitoring found(More)
OBJECTIVE To explore the relationship between hypoxic responsiveness of the patients with narcolepsy-cataplexy and their clinical features. METHODS A total of 113 patients with narcolepsy-cataplexy (narcolepsy group) at Peking University People's Hospital from June 2007 to May 2008 and 128 gender-age matched volunteers (control group) were recruited. And(More)
Sleep medicine has developed into a viable clinical and scientific field over the last four decades; but it is still a little kid compared with other established medical specialties. The knowledge base for sleep medicine is inherently multidisciplinary and involves basic neuroscience, physiology, and behavioral principles, which the sleep clinician can(More)
OBJECTIVE To describe the clinical features and treatment of imported pulmonary histoplasmosis and therefore to improve the recognition and differential diagnosis of this disease. METHODS The clinical data of 3 patients with imported pulmonary histoplasmosis in our hospital were collected and analyzed. Literatures published since 1989 were retrieved with(More)
OBJECTIVE To explore the value of actigraphy and oximetry for diagnosing sleep apnea-hypopnea syndrome (SAHS). METHODS Suspected SAHS subjects were enrolled from sleep center of Peking University People's Hospital between December 2013 and September 2014. Light-out and light-on were simultaneously recorded for polysomnography (PSG), actigraphy and(More)
OBJECTIVE To the evaluate chemo-responsiveness in patients with obesity hypoventilation syndrome (OHS) and respiratory failure (RF). METHODS A total of 14 OHS and RF patients with a mean body mass index (BMI) of (34.3 ± 2.68) kg/m(2) hospitalized between January 2009 to December 2011 were recruited. Lung function test (LFT), polysomnograghy (PSG),(More)