Xiaorong Zhan

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Alzheimer's disease (AD) is known as a leading cause of dementia in elderly persons. It is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction. AD can disrupt functional connectivity in distributed cortical networks. The S-estimator, which is a measure of multivariate intraregional synchronization, was analyzed in this(More)
A sustained loss of Wnt signaling function may be involved in the pathology of Alzheimer's disease (AD). Krüppel-like factor 8 (KLF8) induces the activation of Wnt/β-catenin signaling pathway. Thus, KLF8 may be related with the risk of AD. We want to know the role of KLF8 in the development of AD. A rat brain slice model for AD was established. Quantitative(More)
High-dimensional data and a large number of redundancy features in bioinformatics research have created an urgent need for feature selection. In this paper, a novel random forests-based feature selection method is proposed that adopts the idea of stratifying feature space and combines generalised sequence backward searching and generalised sequence forward(More)
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