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This study explores the feasibility of performing Chinese word segmentation (CWS) and POS tagging by deep learning. We try to avoid task-specific feature engineering, and use deep layers of neural networks to discover relevant features to the tasks. We leverage large-scale unlabeled data to improve internal representation of Chinese characters, and use(More)
We propose a convolutional neural network architecture with <i>k</i>-max pooling layer for semantic modeling of music. The aim of a music model is to analyze and represent the semantic content of music for purposes of classification, discovery, or clustering. The <i>k</i>-max pooling layer is used in the network to make it possible to pool the <i>k</i> most(More)
A polyene macrolide antibiotic tetramycin biosynthetic gene cluster was identified by genome mining and isolated from Streptomyces hygrospinosus var. beijingensis. Genetic and in silico analyses gave insights into the mechanism of biosynthesis of tetramycin, and a model of the tetramycin biosynthetic pathway is proposed. Inactivation of a cytochrome P450(More)
Sunitinib, a multi-targeted tyrosine kinase inhibitor, has been widely used in the therapy of advanced renal cell cancer and imatinib-resistant gastrointestinal stromal tumors. However, little benefits could be obtained from sunitinib for patients with other types of solid tumors including colorectal cancer (CRC). Ethaselen (BBSKE), a specific thioredoxin(More)
BACKGROUND Increased serum level of parathyroid hormone (PTH) was found in metastatic prostate cancers. Calcimimetic R-568 was reported to reduce PTH expression, to suppress cell proliferation and to induce apoptosis in parathyroid cells. In this study, we investigated the effect of R-568 on cellular survival of prostate cancer cells. METHODS Prostate(More)
BACKGROUND Recent advances in Web and information technologies with the increasing decentralization of organizational structures have resulted in massive amounts of information resources and domain-specific services in Traditional Chinese Medicine. The massive volume and diversity of information and services available have made it difficult to achieve(More)
Bacterial phosphorothioate (PT) DNA modifications are incorporated by Dnd proteins A-E and often function with DndF-H as a restriction-modification (R-M) system, as in Escherichia coli B7A. However, bacteria such as Vibrio cyclitrophicus FF75 lack dndF-H, which points to other PT functions. Here we report two novel, orthogonal technologies to map PTs across(More)
Most of today's web content is designed for human consumption, which makes it difficult for software tools to access them readily. Even web content that is automatically generated from back-end databases is usually presented without the original structural information. In this paper, we present an automated information extraction algorithm that can extract(More)
Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction-modification (R-M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R-M systems, highly partial PT modification of consensus motifs in bacterial genomes suggests an unusual mechanism of(More)
Keywords: Travel portal Service-oriented architecture Service-oriented engineering platform (SOEP) Travel alliance a b s t r a c t A service-oriented travel portal is proposed to realize a classic business model with SOA paradigm. It provides tourists with composite travel packages through dynamic composition among travel-related services from distributed(More)