Xiaoqiang Xu

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Phenoporlamine hydrochloride is a novel compound that is used for the treatment of hypertension. The purpose of this study was to develop a sustained release tablet for phenoporlamine hydrochloride because of its short biological half-life. Three floating matrix formulations of phenoporlamine hydrochloride based on gas forming agent were prepared.(More)
The purpose of this work is to design biodegradable Poly(lactide-co-glycolide) (PLGA) microspheres with low initial burst for sustained delivery of Endostar (a novel recombinant human endostatin) and investigate effects of PLGA molecular weight and composition on the release behavior of Endostar microspheres. Endostar microspheres were prepared by using(More)
Recently, interest in phytochemicals from traditional Chinese medicinal herbs with the capability to inhibit cancer cells growth and proliferation has been growing rapidly due to their nontoxic nature. Dysosma versipellis as Bereridaceae plants is an endemic species in China, which has been proved to be an important Chinese herbal medicine because of its(More)
Broadly speaking, the goal of neuromorphic engineering is to build computer systems that mimic the brain. Spiking Neural Network (SNN) is a type of biologically-inspired neural networks that perform information processing based on discrete-time spikes, different from traditional Artificial Neural Network (ANN). Hardware implementation of SNNs is necessary(More)
Vibration analysis is an effective tool for the condition monitoring and fault diagnosis of rolling element bearings. Conventional diagnostic methods are based on the stationary assumption, thus they are not applicable to the diagnosis of bearings working under varying speed. This constraint limits the bearing diagnosis to the industrial application(More)
When operating under harsh condition (e.g., time-varying speed and load, large shocks), the vibration signals of rolling element bearings are always manifested as low signal noise ratio, non-stationary statistical parameters, which cause difficulties for current diagnostic methods. As such, an IMF-based adaptive envelope order analysis (IMF-AEOA) is(More)
Multidrug resistance (MDR) is one of the major obstacles limiting the efficacy of cancer chemotherapy. Identification of new and effective MDR reversal agents is needed. In this study, the effects of polyoxyethylene 40 stearate (PS40) on MDR were evaluated via the transport of the P-glycoprotein (P-gp) substrate vinblastine sulfate (VBL) through Caco-2 cell(More)
Rolling bearings are widely used in rotating equipment. Detection of bearing faults is of great importance to guarantee safe operation of mechanical systems. Acoustic emission (AE), as one of the bearing monitoring technologies, is sensitive to weak signals and performs well in detecting incipient faults. Therefore, AE is widely used in monitoring the(More)
Epithelial-mesenchymal transition (EMT) is a key process in cancer development and progression. Communication (crosstalk) between cancer cells and normal (nonmalignant) cells may facilitate cancer progression. Conditioned medium (CM) obtained from cultured cancer cells contains secreted factors capable of affecting phenotypes and the behaviors of normal(More)
Mechanical fault or defect will cause some weak fluctuations to the position signal. Detection of such fluctuations via encoders can help determine the health condition and performance of the machine, and offer a promising alternative to the vibration-based monitoring scheme. However, besides the interested fluctuations, encoder signal also contains a large(More)