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Traditional Data Mining and Knowledge Discovery algorithms assume free access to data, either at a centralized location or in federated form. Increasingly, privacy and security concerns restrict this access, thus derailing data mining projects. What we need is distributed knowledge discovery that is sensitive to this problem. The key is to obtain valid(More)
Classical data mining algorithms implicitly assume complete access to all data, either in centralized or federated form. However, privacy and security concerns often prevent sharing of data, thus derailing data mining projects. Recently , there has been growing focus on finding solutions to this problem. Several algorithms have been proposed that do(More)
The ability to quickly compute hand geometry measurements from a freely posed hand offers advantages to biometric identification systems. While hand geometry systems are not new, typical measurements of lengths and widths of fingers and palms require rigid placement of the hand against pegs. Slight deviations in hand position, finger stretch or pressure can(More)
We study the problem of short term wind speed prediction , which is a critical factor for effective wind power generation. This is a challenging task due to the complex and stochastic behavior of the wind environment. Observing various periods in the wind speed time series present different patterns, we suggest a nonlin-ear adaptive framework to model(More)
OBJECTIVE Predictive models that generate individualized estimates for medically relevant outcomes are playing increasing roles in clinical care and translational research. However, current methods for calibrating these estimates lose valuable information. Our goal is to develop a new calibration method to conserve as much information as possible, and would(More)
OBJECTIVE Effective data sharing is critical for comparative effectiveness research (CER), but there are significant concerns about inappropriate disclosure of patient data. These concerns have spurred the development of new technologies for privacy-preserving data sharing and data mining. Our goal is to review existing and emerging techniques that may be(More)
Many healthcare facilities enforce security on their electronic health records (EHRs) through a corrective mechanism: some staff nominally have almost unrestricted access to the records, but there is a strict ex post facto audit process for inappropriate accesses, i.e., accesses that violate the facility’s security and privacy policies. This process is(More)
Genome data are becoming increasingly important for modern medicine. As the rate of increase in DNA sequencing outstrips the rate of increase in disk storage capacity, the storage and data transferring of large genome data are becoming important concerns for biomedical researchers. We propose a two-pass lossless genome compression algorithm, which(More)
Determination of the minimum gene set for cellular life is one of the central goals in biology. Genome-wide essential gene identification has progressed rapidly in certain bacterial species; however, it remains difficult to achieve in most eukaryotic species. Several computational models have recently been developed to integrate gene features and used as(More)