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Bisphenol A (BPA) is a ubiquitous plasticizing agent used in the manufacturing of polycarbonate plastics and epoxy resins. There is well-documented and broad human exposure to BPA. The potential risk that BPA poses to the human health has attracted much attention from regulatory agencies and the general public, and has been extensively studied. An emerging(More)
BACKGROUND The need for mechanistic understanding of nonmonotonic dose responses has been identified as one of the major data gaps in the study of bisphenol A (BPA). Previously we reported that acute exposure to BPA promotes arrhythmogenesis in female hearts through alteration of myocyte Ca(2+) handling, and that the dose response of BPA was inverted(More)
BACKGROUND A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy. However, the precise mechanisms affecting SR function and leading to arrhythmias remain elusive. METHODS AND RESULTS We generated transgenic mice(More)
BACKGROUND Bisphenol S (BPS) has increasingly been used as a substitute for bisphenol A (BPA) in some "BPA-free" consumer goods and in thermal papers. Wide human exposure to BPS has been reported; however, the biological and potential toxic effects of BPS are poorly understood. OBJECTIVE In this study, we sought to elucidate the sex-specific rapid effect(More)
  • Janet R Manning, Sarah O Perkins, +5 authors Jo El J Schultz
  • 2013
Among its many biological roles, fibroblast growth factor-2 (FGF2) acutely protects the heart from dysfunction associated with ischemia/reperfusion (I/R) injury. Our laboratory has demonstrated that this is due to the activity of the low molecular weight (LMW) isoform of FGF2 and that FGF2-mediated cardioprotection relies on the activity of protein kinase C(More)
The coming of Network economy era affect people's lifestyles and buying habits, customers who always seek to difference and maximize the value of product start to look for the disparity in order to obtain the maximization of self-perceived value. The growing development of mobile communication networks has increased the formation of disparity, customers(More)
The adventure of 3G communications era means that network marketing will lead the development of the market. Finding a mutual benefit and win-win will push the value of relationship to the peak of research. In this paper, we use mobile communication network as object to study, start from the three-pronged mutual benefits of goods, services, and network,(More)
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