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The Human Connectome Project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce 'functional connectivity'; 2) diffusion imaging (dMRI), which provides the input for tractography(More)
Cloud computing provides people a way to share large mount of distributed resources belonging to different organizations. That is a good way to share many kinds of distributed resources, but it also makes security problems more complicate and more important for users than before. In this paper, we analyze some security requirements in cloud computing(More)
SIRT4, a member of the sirtuin family, has been implicated in the regulation of insulin secretion by modulation of glutamate dehydrogenase. However, the role of this enzyme in the regulation of metabolism in other tissues is unknown. In this study we investigated whether depletion of SIRT4 would enhance liver and muscle metabolic functions. To do this SIRT4(More)
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes appears to involve the generation of double-strand DNA breaks (DSBs) and their error-prone repair. Here we show that DSBs occur at a high frequency in unrearranged (germline) Ig variable (V) genes, BCL6 and c-MYC. These DSBs are blunt, target the mutational RGYW/RGY hotspot, and would be resolved(More)
PURPOSE To develop a new parallel transmit (pTx) pulse design for simultaneous multiband (MB) excitation in order to tackle simultaneously the problems of transmit B1 (B1+) inhomogeneity and total radiofrequency (RF) power, so as to allow for optimal RF excitation when using MB pulses for slice acceleration for high and ultrahigh field MRI. METHODS With(More)
Mobile agent, as a promising distributed computing technology, can be used in many fields. The security problem of mobile agent is important for applications based on mobile agent technology. In this paper, we proposed a trust management model for mobile agent system to improve the security of the mobile agent system. In this model, the security of mobile(More)
[1] Precise GPS measurements of elastic relative site displacements due to surface mass loading offer important constraints on global surface mass transport. We investigate effects of site distribution and aliasing by higher-degree (n 2) loading terms on inversion of GPS data for n = 1 load coefficients and geocenter motion. Covariance and simulation(More)
Traumatic brain injury (TBI) is associated with coagulopathy, although it often lacks 2 key risk factors: severe bleeding and significant fluid resuscitation associated with hemorrhagic shock. The pathogenesis of TBI-associated coagulopathy remains poorly understood. We tested the hypothesis that brain-derived microparticles (BDMPs) released from an injured(More)
PURPOSE Cortical tubers are epileptogenic lesions in patients with tuberous sclerosis complex (TSC). Giant cells and dysplastic neurons are pathological hallmarks of cortical tubers. Severe astrogliosis, which is invariably present in tubers, has attracted much less attention. We hypothesize that the development of astrogliosis in cortical tubers(More)