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Centromeres play a critical role in chromosome inheritance but are among the most difficult genomic components to analyze in multicellular eukaryotes. Here, we present a highly detailed molecular structure of a functional centromere in a multicellular organism. The centromere of the Drosophila minichromosome Dp1187 is contained within a 420 kb region of(More)
It is important to help researchers find valuable scientific papers from a large literature collection containing information of authors, papers and venues. Graph-based algorithms have been proposed to rank papers based on networks formed by citation and co-author relationships. This paper proposes a new graph-based ranking framework MutualRank that(More)
A semantic link peer-to-peer (P2P) network specifies and manages semantic relationships between peers' data schemas and can be used as the semantic layer of a scalable Knowledge Grid. The proposed approach consists of an automatic semantic link discovery method, a tool for building and maintaining P2P semantic link networks (P2PSLNs), a semantic-based peer(More)
Reducing oxidative damage is thought to be an effective aging intervention. Açai, a fruit indigenous to the Amazon, is rich in phytochemicals that possesses high anti-oxidant activities, and has anti-inflammatory, anti-cancer and anti-cardiovascular disease properties. However, little is known about its potential anti-aging properties especially at the(More)
Horizontal cells send inhibitory feedback to photoreceptors, helping form antagonistic receptive fields in the retina, but the neurotransmitter and the mechanisms underlying this signalling are not known. Since the proteins responsible for conventional Ca(2+)-dependent release of GABAergic synaptic vesicles are present in mammalian horizontal cells, we(More)
The knowledge grid needs to operate with a scalable platform to provide large-scale intelligent services. A key function of such a platform is to efficiently support various complex queries in a dynamic large-scale network environment. This paper proposes a platform to support index-based path queries by incorporating a semantic overlay with an underlying(More)
This paper presents Harmonic Ring (HRing), a structured peer-to-peer (P2P) overlay where long links are built along the ring with decreasing probabilities coinciding with the Harmonic Series. HRing constructs routing tables based on the distance between node positions instead of node IDs in order to eliminate the effect of node ID distribution on the long(More)
To improve search efficiency and reduce unnecessary traffic in Peer-to-Peer (P2P) networks, this paper proposes a trust-based probabilistic search algorithm, called preferential walk (P-Walk). Every peer ranks its neighbors according to searching experience. The highly ranked neighbors have higher probabilities to be queried. Simulation results show that(More)