Xiaonong Sean Zhu

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Scaffold molecules interact with multiple effectors to elicit specific signal transduction pathways. CIITA, a non-DNA-binding regulator of class II major histocompatibility complex (MHC) gene transcription, may serve as a transcriptional scaffold. Regulation of the class II MHC promoter by CIITA requires strict spatial-helical arrangements of the X and Y(More)
The CIITA coactivator is essential for transcriptional activation of MHC class II genes and mediates enhanced MHC class I transcription. We now report that CIITA contains an intrinsic acetyltransferase (AT) activity that maps to a region within the N-terminal segment of CIITA, between amino acids 94 and 132. The AT activity is regulated by the C-terminal(More)
The presence of the class II transactivator (CIITA) activates the transcription of all MHC class II genes. Previously, we reported that deletion of a carboxyl-terminal nuclear localization signal (NLS) results in the cytoplasmic localization of CIITA and one form of the type II bare lymphocyte syndrome. However, further sequential carboxyl-terminal(More)
Single-crystal (SC) fibers have the potential of delivering extremely high laser energies. Sapphire fibers have been the most commonly studied SC fiber and the losses for sapphire fibers have been as low as 0.4 dB/m for a 300micron core-only fiber at 3 microns. In this study we report on the growth of SC yttrium aluminum garnet, Y3Al5O12 (YAG) fibers from(More)
MHC class II deficiency found in bare lymphocyte syndrome patients results from the absence or dysfunction of MHC class II transcriptional regulators, such as regulatory factor X (RFX) and class II transactivator (CIITA). Understanding the roles of these factors has been greatly facilitated by the study of genetic defects in cell lines of bare lymphocyte(More)
The present paper examines what kinds of Shanghai disyllabic lexical tone sandhi undergoes, especially in what sense and to what extent a disyllabic tone can be claimed to result from rightward spreading of the corresponding citation tone. It will be shown that F0 spreading occurs in the Long tone domains while Contour element spreading mainly in the Short(More)
The class II transactivator (CIITA) is induced by gamma interferon (IFN-gamma) and activates major histocompatibility complex class II; however, this report shows it suppresses other genes. An N-terminal 36 amino acids of CIITA mediates suppression of the collagen alpha(2)(I) promoter via binding to CREB-binding protein (CBP). Reconstitution of cells with(More)
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