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Genic microsatellite markers, also known as functional markers, are preferred over anonymous markers as they reveal the variation in transcribed genes among individuals. In this study, we developed a total of 707 expressed sequence tag-derived simple sequence repeat markers (EST-SSRs) and used for development of a high-density integrated map using four(More)
Medulloblastoma, the most common malignant paediatric brain tumour, arises in the cerebellum and disseminates through the cerebrospinal fluid in the leptomeningeal space to coat the brain and spinal cord. Dissemination, a marker of poor prognosis, is found in up to 40% of children at diagnosis and in most children at the time of recurrence. Affected(More)
In the present study, we investigated whether omentin affected the expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in tumor necrosis factor-α (TNF-α) induced human umbilical vein endothelial cells (HUVECs). Our data showed that omentin decreased TNF-α-induced expression of ICAM-1 and VCAM-1 in HUVECs.(More)
Medulloblastoma is the most common malignant brain tumor in children. Although the prognosis has improved considerably, leptomeningeal spread of the tumor remains a significantly negative predictor of survival. Mitochondrial DNA (mtDNA) mutations have been detected in many types of human tumors but not in medulloblastomas. Using temporal temperature(More)
Development of effective therapeutic strategies to eliminate cancer stem cells, which play a major role in drug resistance and disease recurrence, is critical to improve cancer treatment outcomes. Our study showed that glioblastoma stem cells (GSCs) exhibited low mitochondrial respiration and high glycolytic activity. These GSCs were highly resistant to(More)
With the rapid growth of databases in many modern enterprises data mining has become an increasingly important approach for data analysis. The operations research community has contributed significantly to this field, especially through the formulation and solution of numerous data mining problems as optimization problems, and several operations research(More)
Chinese cabbage (Brassica rapa L. ssp. pekinensis) is one of the most important vegetables in China. Genetic dissection of leaf mineral accumulation and tolerance to Zn stress is important for the improvement of the nutritional quality of Chinese cabbage by breeding. A mapping population with 183 doubled haploid (DH) lines was used to study the genetics of(More)
We introduce EntityEngine, a system for answering entity-relationship queries over text. Such queries combine SQL-like structures with IR-style keyword constraints and therefore, can be expressive and flexible in querying about entities and their relationships. EntityEngine consists of various offline and online components, including a position-based(More)
Wikipedia is the largest user-generated knowledge base. We propose a structured query mechanism, <i>entity-relationship query</i>, for searching entities in Wikipedia corpus by their properties and inter-relationships. An entity-relationship query consists of arbitrary number of predicates on desired entities. The semantics of each predicate is specified(More)