Xiaona Sheng

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Toshihide Kashihara1
Toshifumi Aoyama1
Toshihide Shibazaki1
1Toshihide Kashihara
1Toshifumi Aoyama
1Toshihide Shibazaki
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Dihydropyridine Ca(2+) channel antagonists (DHPs) block Ca(V)1.2 L-type Ca(2+) channels (LTCCs) by stabilizing their voltage-dependent inactivation (VDI); however, it is still not clear how DHPs allosterically interact with the kinetically distinct (fast and slow) VDI. Thus, we analyzed the effect of a prototypical DHP, nifedipine on LTCCs with or without(More)
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