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It has been proven that c-kit is crucial for proliferation, migration, survival and maturation of spermatogenic cells. A periodic expression of c-kit is observed from primordial germ cells (PGCs) to spermatogenetic stem cells (SSCs), However, the expression profile of c-kit during the entire spermatogenesis process is still unclear. This study aims to(More)
CaGdGaAl2O7 and CaGdGaAl2O7:Ce(3+),Tb(3+) have been synthesized by a traditional solid state reaction for the first time. The Rietveld refinement confirmed that CaGdGaAl2O7 has a tetragonal crystal system with the space group P4[combining macron]21m. The photoluminescence properties show that the obtained phosphors can be efficiently excited in the range(More)
The zona pellucida (ZP) is an extracellular matrix universally surrounding mammalian eggs, which is essential for oogenesis, fertilization, and pre-implantation embryo development. Here, we identified two novel heritable mutations of ZP2 and ZP3, both occurring in an infertile female patient with ZP-abnormal eggs. Mouse models with the same mutations were(More)
Human female germline stem cells (FGSCs) have opened new opportunities for understanding human oogenesis, delaying menopause, treating infertility, and providing a new strategy for preserving fertility. However, the shortage of adult human ovaries tissues available impedes their future investigations and clinical applications. Here, we have established FGSC(More)
AIM This study aimed to compare the efficacy of long- and short-acting gonadotropin-releasing hormone agonist on clinical outcomes of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) long protocol cycles. METHODS In this retrospective study, 478 patients were enrolled from October 2012 to November 2014. The pituitary downregulation(More)
INTRODUCTION This article provides a new method to avoid recurrent ectopic pregnancy during IVF-ET treatment in women who underwent bilateral salpingectomy. MATERIALS AND METHODS A Chinese woman who underwent bilateral salpingectomy because of previous ectopic pregnancy sought IVF-ET therapy. She got two continuous salpingocyesis in fresh cycle and frozen(More)
Generating male germ cells in vitro from multipotent stem cells is still a challenge for stem cell biologists. The difficulty is caused by the lack of knowledge about spermatogenesis molecular-controlling mechanisms. In vivo, PGCs differentiate into male germ cells in a very complicated environment through many middle steps. In this study, we use the(More)
OBJECTIVE We studied the effects of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) on the proliferation of porcine theca interna (TI) cells and further elucidated the roles of IL-6 and TNF-α in the pathogenesis of polycystic ovary syndrome. MATERIALS AND METHODS TI cells were treated with 10 pg/mL, 100 pg/mL, and 1000 pg/mL IL-6 or TNF-α. TI(More)
OBJECTIVE To develop a unique approach using polarization microscopy (PM) to determine whether the presence of a spindle can be used as an indicator associated with fertilization failure 5 hours after short-term insemination. DESIGN Observational study. SETTING Assisted reproduction center. PATIENT(S) Eighty-five patients undergoing short-term(More)
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