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Newly generated actin free barbed ends at the front of motile cells provide sites for actin filament assembly driving membrane protrusion. Growth factors induce a rapid biphasic increase in actin free barbed ends, and we found both phases absent in fibroblasts lacking H(+) efflux by the Na-H exchanger NHE1. The first phase is restored by expression of(More)
Traditional text categorization is usually a topic-based task, but a subtle demand on information retrieval is to distinguish between positive and negative view on text topic. In this paper, a new method is explored to solve this problem. Firstly, a batch of Concerned Concepts in the researched domain is predefined. Secondly, the special knowledge(More)
Recently, general-purpose graphics processing units (GPGPUs) have been widely used to accelerate computing in various applications. To store the contexts of thousands of concurrent threads on a GPU, a large static random-access memory (SRAM)-based register file is employed. Due to high leakage power of SRAM, the register file consumes 20% to 40% of the(More)
Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodium assembly and maturation and show that invadopodia use cortactin phosphorylation as a master switch during these processes. In particular, cortactin(More)
Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and temporal regulation of actin cytoskeleton by actin-binding proteins (ABPs). It is generally hypothesized that the activity of many ABPs are temporally and spatially regulated by PIP(2); however,(More)
Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine-threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin(More)
This paper reviews emerging wireless information and power transfer (WIPT) technique with an emphasis on its performance enhancement employing multi-antenna techniques. Compared to traditional wireless information transmission, WIPT faces numerous challenges. First, it is more susceptible to channel fading and path loss, resulting in a much shorter power(More)
—In this paper, we consider a multi-antenna system where the receiver should harvest energy from the transmitter by wireless energy transfer to support its wireless information transmission. In order to maximize the harvesting energy, we propose to perform adaptive energy beamforming according to the instantaneous channel state information (CSI). To help(More)
BACKGROUND RhoGTPases have been implicated in the regulation of cancer metastasis. Invasive carcinoma cells form invadopodia, F-actin-rich matrix-degrading protrusions that are thought to be important for tumor cell invasion and intravasation. Regulation of actin dynamics at invadopodial protrusions is crucial to drive invasion. This process requires the(More)
—In this paper, we address the problem of interference alignment (IA) over MIMO interference channels with limited channel state information (CSI) feedback based on quantization codebooks. Due to limited feedback and hence imperfect IA, there are residual interferences across different links and different data streams. As a result, the performance of IA is(More)