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Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodium assembly and maturation and show that invadopodia use cortactin phosphorylation as a master switch during these processes. In particular, cortactin(More)
Recently, general-purpose graphics processing units (GPGPUs) have been widely used to accelerate computing in various applications. To store the contexts of thousands of concurrent threads on a GPU, a large static random-access memory (SRAM)-based register file is employed. Due to high leakage power of SRAM, the register file consumes 20% to 40% of the(More)
Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and temporal regulation of actin cytoskeleton by actin-binding proteins (ABPs). It is generally hypothesized that the activity of many ABPs are temporally and spatially regulated by PIP(2); however,(More)
BACKGROUND RhoGTPases have been implicated in the regulation of cancer metastasis. Invasive carcinoma cells form invadopodia, F-actin-rich matrix-degrading protrusions that are thought to be important for tumor cell invasion and intravasation. Regulation of actin dynamics at invadopodial protrusions is crucial to drive invasion. This process requires the(More)
PURPOSE To estimate the prevalence of dry eye disease, analyze the associations between dry eye symptoms and signs, and identify the risk factors in an elderly Mongolian population at high altitude in China. METHODS A population-based survey was conducted in 2006. A total of 2,486 Mongolians age 40 and older were selected. Symptoms of dry eye were(More)
—In this paper, we consider a multi-antenna system where the receiver should harvest energy from the transmitter by wireless energy transfer to support its wireless information transmission. In order to maximize the harvesting energy, we propose to perform adaptive energy beamforming according to the instantaneous channel state information (CSI). To help(More)
Imaging of Ca 2ϩ dynamics within the presynaptic terminals of salamander rod photoreceptors.though the overall importance of Ca 2ϩ as a mediator of cell signaling and neurotransmitter release has long been appreciated, the details of Ca 2ϩ dynamics within the inner segments of vertebrate rod photore-ceptors are just beginning to be elucidated. Even less is(More)
PURPOSE Mutations in the CACNA1F gene encoding the L-type calcium channel pore-forming Ca(v)1.4 (alpha1F) subunit in humans result in an incomplete form of congenital stationary night blindness (CSNB2) with residual photoreceptor function. It has been postulated that this residual function, at least in part, may be mediated by another L-type calcium channel(More)
Sparse solver has become the bottleneck of SPICE simulators. There has been few work on GPU-based sparse solver because of the high data-dependency. The strong data-dependency determines that parallel sparse LU factorization runs efficiently on shared-memory computing devices. But the number of CPU cores sharing the same memory is often limited. The state(More)
Traditional text categorization is usually a topic-based task, but a subtle demand on information retrieval is to distinguish between positive and negative view on text topic. In this paper, a new method is explored to solve this problem. Firstly, a batch of Concerned Concepts in the researched domain is predefined. Secondly, the special knowledge(More)