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Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodium assembly and maturation and show that invadopodia use cortactin phosphorylation as a master switch during these processes. In particular, cortactin(More)
—In this paper, we consider a multi-antenna system where the receiver should harvest energy from the transmitter by wireless energy transfer to support its wireless information transmission. In order to maximize the harvesting energy, we propose to perform adaptive energy beamforming according to the instantaneous channel state information (CSI). To help(More)
Imaging of Ca 2ϩ dynamics within the presynaptic terminals of salamander rod photoreceptors.though the overall importance of Ca 2ϩ as a mediator of cell signaling and neurotransmitter release has long been appreciated, the details of Ca 2ϩ dynamics within the inner segments of vertebrate rod photore-ceptors are just beginning to be elucidated. Even less is(More)
PURPOSE Mutations in the CACNA1F gene encoding the L-type calcium channel pore-forming Ca(v)1.4 (alpha1F) subunit in humans result in an incomplete form of congenital stationary night blindness (CSNB2) with residual photoreceptor function. It has been postulated that this residual function, at least in part, may be mediated by another L-type calcium channel(More)
Traditional text categorization is usually a topic-based task, but a subtle demand on information retrieval is to distinguish between positive and negative view on text topic. In this paper, a new method is explored to solve this problem. Firstly, a batch of Concerned Concepts in the researched domain is predefined. Secondly, the special knowledge(More)
Recently, general-purpose graphics processing units (GPGPUs) have been widely used to accelerate computing in various applications. To store the contexts of thousands of concurrent threads on a GPU, a large static random-access memory (SRAM)-based register file is employed. Due to high leakage power of SRAM, the register file consumes 20% to 40% of the(More)
Holmes et al. (Holmes, K. C., D. Popp, W. Gebhard, and W. Kabsch. 1990. Nature [Lond.] 347: 44-49) hypothesized that between subdomains 3 and 4 of actin is a loop of 10 amino acids including a four residue hydrophobic plug that inserts into a hydrophobic pocket formed by two adjacent monomers on the opposing strand thereby stabilizing the F-actin helix. To(More)
Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine-threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin(More)
Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and temporal regulation of actin cytoskeleton by actin-binding proteins (ABPs). It is generally hypothesized that the activity of many ABPs are temporally and spatially regulated by PIP(2); however,(More)