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Invadopodia are matrix-degrading membrane protrusions in invasive carcinoma cells. The mechanisms regulating invadopodium assembly and maturation are not understood. We have dissected the stages of invadopodium assembly and maturation and show that invadopodia use cortactin phosphorylation as a master switch during these processes. In particular, cortactin(More)
Lamellipodial protrusion and directional migration of carcinoma cells towards chemoattractants, such as epidermal growth factor (EGF), depend upon the spatial and temporal regulation of actin cytoskeleton by actin-binding proteins (ABPs). It is generally hypothesized that the activity of many ABPs are temporally and spatially regulated by PIP(2); however,(More)
—In this paper, we consider a multi-antenna system where the receiver should harvest energy from the transmitter by wireless energy transfer to support its wireless information transmission. In order to maximize the harvesting energy, we propose to perform adaptive energy beamforming according to the instantaneous channel state information (CSI). To help(More)
Imaging of Ca 2ϩ dynamics within the presynaptic terminals of salamander rod photoreceptors.though the overall importance of Ca 2ϩ as a mediator of cell signaling and neurotransmitter release has long been appreciated, the details of Ca 2ϩ dynamics within the inner segments of vertebrate rod photore-ceptors are just beginning to be elucidated. Even less is(More)
PURPOSE Mutations in the CACNA1F gene encoding the L-type calcium channel pore-forming Ca(v)1.4 (alpha1F) subunit in humans result in an incomplete form of congenital stationary night blindness (CSNB2) with residual photoreceptor function. It has been postulated that this residual function, at least in part, may be mediated by another L-type calcium channel(More)
PURPOSE To estimate the prevalence of dry eye disease, analyze the associations between dry eye symptoms and signs, and identify the risk factors in an elderly Mongolian population at high altitude in China. METHODS A population-based survey was conducted in 2006. A total of 2,486 Mongolians age 40 and older were selected. Symptoms of dry eye were(More)
Traditional text categorization is usually a topic-based task, but a subtle demand on information retrieval is to distinguish between positive and negative view on text topic. In this paper, a new method is explored to solve this problem. Firstly, a batch of Concerned Concepts in the researched domain is predefined. Secondly, the special knowledge(More)
Recently, general-purpose graphics processing units (GPGPUs) have been widely used to accelerate computing in various applications. To store the contexts of thousands of concurrent threads on a GPU, a large static random-access memory (SRAM)-based register file is employed. Due to high leakage power of SRAM, the register file consumes 20% to 40% of the(More)
Understanding the mechanisms controlling cancer cell invasion and metastasis constitutes a fundamental step in setting new strategies for diagnosis, prognosis, and therapy of metastatic cancers. LIM kinase1 (LIMK1) is a member of a novel class of serine-threonine protein kinases. Cofilin, a LIMK1 substrate, is essential for the regulation of actin(More)
The objective of this study was to investigate the distribution of mutations in the Cytochrome P450 1B1 gene (CYP1B1) in patients with primary congenital glaucoma (PCG) among different populations. All identifiable original studies on CYP1B1 gene mutations of patients with PCG were reviewed. Finally, DNA mutations within the CYP1B1 gene were identified in(More)