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Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway.
Liver cancer is a malignant tumour with high morbidity and fatality rates that is common worldwide. At present, the clinical approaches to treating primary liver cancer include partial hepatectomy,Expand
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Stereoselective synthesis of jaspine B from D-xylose.
The natural cytotoxic marine compound, jaspine B, is stereoselectively synthesized from D-xylose in 11 linear steps with a 23.9% overall yield. The key step in the synthesis involves anExpand
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MicroRNA-1 in Cardiac Diseases and Cancers
MicroRNAs (miRs) are endogenous ≈22-nt non-coding RNAs that participate in the regulation of gene expression at post-transcriptional level. MiR-1 is one of the muscle-specific miRs, aberrantExpand
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LPCAT1 promotes brain metastasis of lung adenocarcinoma by up-regulating PI3K/AKT/MYC pathway
BackgroundBrain metastasis (BM) is associated with poor prognosis, recurrence, and death in patients with non-small cell lung cancer (NSCLC). Lysophosphatidylcholine acyltransferase 1 (LPCAT1) hasExpand
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Potential role of ATM in hepatocyte endocytosis of ApoE-deficient, ApoB48-containing lipoprotein in ApoE-deficient mice
  • J. Wu, Yanhong Xiao, +5 authors D. Wu
  • Medicine, Biology
  • International journal of molecular medicine
  • 26 November 2013
Individuals carrying mutations at both ataxia telangiectasia mutated (ATM) gene alleles reportedly have increased plasma cholesterol and triglyceride levels. Previous studies have demonstrated thatExpand
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Long Noncoding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System
Less than 3 % of the human genome encodes protein sequences and the majority of transcribed sequences are noncoding. Long noncoding RNAs (lncRNAs) refer to transcripts lacking in protein-codingExpand
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Palbinone alleviates diabetic retinopathy in STZ‐induced rats by inhibiting NLRP3 inflammatory activity
Diabetic retinopathy (DR) is the primary cause of blindness and visual impairment in diabetes patients worldwide. However, laser and surgical therapies at DR have short‐term effectiveness and causeExpand
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An integrated global regulatory network of hematopoietic precursor cell self-renewal and differentiation.
Systematic study of the regulatory mechanisms of Hematopoietic Stem Cell and Progenitor Cell (HSPC) self-renewal is fundamentally important for understanding hematopoiesis and for manipulating HSPCsExpand
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Effects of rhaponticin on retinal oxidative stress and inflammation in diabetes through NRF2/HO-1/NF-κB signalling.
Oxidative stress and inflammation have long been considered to be responsible for the development and progression of diabetic retinopathy. On the other hand, rhaponticin (RN) has received scientificExpand