Xiaomeng Nie

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IL -10 is widely accepted as a survival, proliferation, and differentiation factor for B cells. However, IL-10 deficiency accelerates disease progression as the result of autoantibody production in many autoimmune disease models. It was demonstrated that T follicular helper cells (T(FH) cells) play a key role in helping B cells that are secreting Abs. In(More)
Affiliations: Drs. Winchester, Macfarlane, Thomas, and Price are affiliated with the University of Aberdeen. Financial/nonfinancial disclosures: Dr. Winchester is employed as a medical writer by Oxford PharmaGenesis Ltd. He and Oxford PharmaGenesis have received no industry funding for this research and are undertaking no industry-sponsored projects related(More)
BACKGROUND Gene transfer using inducible promoters, which control expression of transgenic proteins in response to physiological conditions, may have significant advantages. In this study, we tried to achieve an inducible adenoviral expression system for physiologically responsive gene therapy of autoimmune or inflammatory diseases. METHODS A luciferase(More)
OBJECTIVE Existing oncology performance status measurements are used to predict chemotherapy toxicity in all patients with cancer, regardless of age. A new predictive model for grade 3-5 chemotherapy toxicities was developed by Hurria et al. (2011).(1) As the model is from the Cancer and Aging Research Group (CARG), we call it the CARG toxicity tool. We(More)
while higher than that found in a survey by the American College of Chest Physicians (4.6%).3 Among complications, bleeding occurred most frequently. Most bleeding occurred during brush and forceps biopsies. The death rate was 0.076%. Although the number of hospitals in the survey was relatively small, this was the first nationwide survey on bronchoscopy(More)
OBJECTIVE The aim of this study was to investigate the number of Clara cells and the production and secretion of Clara cell 16 kDa protein (CC16) in a murine model of allergen-induced airway inflammation, as well as the effects of N-acetylcysteine (NAC) on CC16 and Clara cell numbers, in order to determine the mechanism of the anti-inflammatory effect of(More)
Pulmonary surfactant protein D (SP-D) is a member of the collectin family and plays crucial roles in the innate immunity of the lung. We have previously shown that surfactant protein A (SP-A), a homologous collectin, interacts with MD-2 and alters lipopolysaccharide signaling. In this study, we examined and characterized the binding of SP-D to MD-2 using a(More)
OBJECTIVE To summarize the clinical features, diagnosis and treatment experience of IgG4-related lung disease for the sake of improving clinical understanding of this disease and reducing the misdiagnosis and mistreatment rates. METHODS To analyze the general situation, clinical manifestation, laboratory examination, histopathology, therapy and prognosis(More)
BACKGROUND Though the possibility of using malignant pleural effusions (MPEs) as alternatives for metastatic pleural tumor tissues (MPTTs) in epidermal growth factor receptor (EGFR) mutation test has been examined, due to the lack of studies comparing the results in matching MPEs and MPTTs, the clinical value of MPEs for advanced adenocarcinoma patients(More)
T cell antiviral function is impaired during chronic hepatitis B (CHB). Programmed death-1 (PD-1) impairs antiviral T cell responses, but dysfunction is not always reversed by blockade of PD-1 pathway. Whether distinct T cell populations expressing different sets of inhibitory molecules exist has not been determined. We studied the expression of the B and T(More)