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Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia
- Xiaomeng Huang, S. Schwind, +17 authors G. Marcucci
- Medicine, Biology
- Clinical Cancer Research
- 14 March 2013
Tf-NP effectively delivered functional miR-29b, resulting in target downregulation and antileukemic activity and warrants further investigation as a novel therapeutic approach in AML. Expand
Targeting Leukemia Stem Cells in vivo with AntagomiR-126 Nanoparticles in Acute Myeloid Leukemia
It is suggested that by targeting a single miR, that is, miR-126, it is possible to interfere with LSC activity, thereby opening potentially novel therapeutic approaches to treat AML patients. Expand
SPARC promotes leukemic cell growth and predicts acute myeloid leukemia outcome.
- H. Alachkar, R. Santhanam, +28 authors G. Marcucci
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 2014
It is found that SPARC overexpression is associated with adverse outcome in CN-AML patients and promotes aggressive leukemia growth in murine models of AML. Expand
Targeting the RAS/MAPK pathway with miR-181a in acute myeloid leukemia
It is reported that miR-181a directly binds to 3′-untranslated regions (UTRs); downregulates KRAS, NRAS and MAPK1; and decreases AML growth, and that targeting the RAS-MAPK-pathway by miR -181a mimics represents a novel promising therapeutic approach for AML and possibly for other Ras-driven cancers. Expand
Implications of the miR-10 family in chemotherapy response of NPM1-mutated AML.
It was found that high baseline miR-10 family expression in 54 untreated cytogenetically heterogeneous AML patients was associated with achieving CR, and when the NPM1 mutation status was included in the multivariable model, there was a significant interaction effect between mi R-10a-5p expression and NPM 1 mutation status. Expand
MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate.
It is revealed that mouse and human models with a time-series single-cell transcriptome analysis reveal that MYC drives dynamic evolution of SCLC subtypes, suggesting that genetics, cell of origin, and tumor cell plasticity determine SclC subtype. Expand
Detection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons.
A novel assay by which tethered cationic lipoplex nanoparticles containing molecular beacons (MBs) can capture cancer cell-derived exosomes or viruses and identify encapsulated RNAs in a single step is presented. Expand
A microfluidic method to synthesize transferrin-lipid nanoparticles loaded with siRNA LOR-1284 for therapy of acute myeloid leukemia.
Results suggest that Tf-conjugated NPs prepared by MHF provide a suitable platform for efficient and specific therapeutic delivery of LOR-1284 into acute myeloid leukemia (AML) cells. Expand
Controllable Large-Scale Transfection of Primary Mammalian Cardiomyocytes on a Nanochannel Array Platform.
A high-throughput nanoelectroporation technique based on a nanochannel array platform is reported, which enables massively parallel delivery of genetic cargo into mouse primary cardiomyocytes in a controllable, highly efficient, and benign manner. Expand
Targeted delivery of tumor suppressor microRNA-1 by transferrin-conjugated lipopolyplex nanoparticles to patient-derived glioblastoma stem cells.
- Xinmei Wang, Xiaomeng Huang, +6 authors L. J. Lee
- Chemistry, Medicine
- Current pharmaceutical biotechnology
- 31 August 2014
It is shown that a transferrin-targeting non-invasive nanoparticle delivery system (Tf- NP) can efficiently deliver miR-1 to GBM patient-derived GSC-enriched sphere cultures (GBM spheres) and supported that Tf-NP could be used as an efficient and effective delivery system which has high potential to benefit the development of mi R-based therapeutics for GBM treatment. Expand