Xiaomei Wu

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A map of protein-protein interactions provides valuable insight into the cellular function and machinery of a proteome. By measuring the similarity between two Gene Ontology (GO) terms with a relative specificity semantic relation, here, we proposed a new method of reconstructing a yeast protein-protein interaction map that is solely based on the GO(More)
BACKGROUND Since proteins perform their functions by interacting with one another and with other biomolecules, reconstructing a map of the protein-protein interactions of a cell, experimentally or computationally, is an important first step toward understanding cellular function and machinery of a proteome. Solely derived from the Gene Ontology (GO), we(More)
High-throughput studies of protein interactions may have produced, experimentally and computationally, the most comprehensive protein-protein interaction datasets in the completely sequenced genomes. It provides us an opportunity on a proteome scale, to discover the underlying protein interaction patterns. Here, we propose an approach to discovering motif(More)
BACKGROUND Although diabetic retinopathy (DR) is considered to be a major cause of blindness, this is the first meta-analysis to investigate the pooled prevalence of DR in mainland China. METHODOLOGY/PRINCIPAL FINDINGS We conducted a search of all English reports on population-based studies for the prevalence of DR using Medline, EMbase, Web of Science,(More)
Electromagnetic tracking, a non-fluoroscopic image navigation method most often used in minimally invasive therapy, has prominent advantages and features over the traditional X-ray radioscopy. Using two rotating coils and one 3-axis magnetic sensor, a novel 6 degree of freedom (DOF) electromagnetic tracking method is proposed in this paper. Two alternate(More)
PURPOSE To identify clinical features and mutations within the transforming growth factor-beta-induced (TGFBI) gene in three Chinese families with Granular corneal dystrophy, type 1 (GCD1) and Granular corneal dystrophy, type 2 (GCD2). METHODS Clinical features of GCD1 and GCD2 in three Chinese families were studied with slit-lamp and in vivo laser(More)
BACKGROUND Chronic obstructive pulmonary disease (COPD) is influenced by both environmental and genetic factors. ADAM33 (a disintegrin and metalloproteinase 33) has been one of the most exciting candidate genes for asthma since its first association with the disease in Caucasian populations. Recently, ADAM33 was shown to be associated with excessive decline(More)
The zero bias stability, which is an important performance parameter for vibratory cylinder gyroscopes, is high sensitive to temperature change. It is considered that the varying temperature makes the vibration mode axes unstable, which has significant influence on the zero bias stability. This paper will investigate this problem in detail. First, the(More)
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, had significant effects on the homocysteine levels. The common functional MTHFR C677T polymorphism had been extensively researched. Several studies had evaluated the relationship between MTHFR C677T polymorphism and type 2 diabetes mellitus (T2DM), but the results(More)