Xiaolu Xiong

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In contrast to typical laboratory experiments, the everyday use of online educational resources by large populations and the prevalence of software infrastructure for A/B testing leads us to consider how platforms can embed in vivo experiments that do not merely support research, but ensure practical improvements to their educational components. Examples(More)
BACKGROUND Rickettsia heilongjiangensis, the agent of Far-Eastern spotted fever (FESF), is an obligate intracellular bacterium. The surface-exposed proteins (SEPs) of rickettsiae are involved in rickettsial adherence to and invasion of host cells, intracellular bacterial growth, and/or interaction with immune cells. They are also potential molecular(More)
Coxiella burnetii is the etiological agent of Q fever. The clinical diagnosis of Q fever is mainly based on several serological tests. These tests all need Coxiella organisms which are difficult and hazardous to culture and purify. An immunoproteomic study of C. burnetii Xinqiao strain isolated in China was conducted with the sera from experimentally(More)
Far-eastern spotted fever is an emerging disease caused by Rickettsia heilongjiangensis, a tick-borne obligate intracellular bacterium. In this study, R. heilongjiangensis was used to infect BALB/c mice by inoculation of retro-orbital venous plexus to imitate a blood infection caused by tick biting. We found that R. heilongjiangensis rapidly entered the(More)
Researchers of Intelligent Tutoring Systems (ITS) and Educational Data Mining (EDM) have focused increasing attention on predicting students' long-term retention performance as well as attempting to find effective methods to help improve student knowledge retention. Wang and Beck proposed a system which allows ITS to strive for student long-term mastery(More)
Student modeling has been widely used in the prediction of student correctness behavior on the immediate next action. Some researchers have been working on student modeling to predict delayed performance, that is, retention. Prior work has found that the factors influencing retention differ from those that influence short-term performance. However, this(More)
Coxiella burnetii is the etiological agent of human Q fever. In this study, adaptive transfer of mouse bone marrow-derived dendritic cells (BMDCs) stimulated with C. burnetii antigen, phase I whole-cell antigen (PIAg), lipopolysaccharide (LPS)-removed PIAg (PIIAg), protein antigen Com1, or SecB significantly reduced coxiella burden in recipient mice(More)
BACKGROUND Surface proteins YbgF and PrsA are major seroreactive antigens of Rickettsia heilongjiangensis, the etiological agent of Far-Eastern spotted fever. This study investigated their potential immunogenicity for protective immunity. METHODS Recombinant YbgF and PrsA were used to immunize C3H/HeN mice and rickettsial loads in immunized mouse organs(More)