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Potential serodiagnostic markers for Q fever identified in Coxiella burnetii by immunoproteomic and protein microarray approaches
TLDR
It is demonstrated that these 7 Coxiella proteins gave a modest sensitivity and specificity for recognizing of Q fever patient sera, suggesting that they are potential serodiagnostic markers for Q fever.
Proteome Analysis and Serological Characterization of Surface-Exposed Proteins of Rickettsia heilongjiangensis
TLDR
Bioinformatics analysis suggests that these proteins could be involved in bacterial pathogenesis, and many of the SEPs identified herein have potentially important roles in R. heilongjiangensis pathogenicity.
Exploratory Study on Th1 Epitope-Induced Protective Immunity against Coxiella burnetii Infection
TLDR
Immunization with the pool of 7 peptide, but not the individual peptides, conferred a significant protection against C. burnetii infection in mice, suggesting that these Th1 peptides could work together to efficiently activate CD4+ T cells to produce the Th1-type immune response against Coxiella burnsetii.
Efficient activation of T cells by human monocyte-derived dendritic cells (HMDCs) pulsed with Coxiella burnetii outer membrane protein Com1 but not by HspB-pulsed HMDCs
TLDR
It is demonstrated that Com1-pulsed HMDCs are able to induce efficient T-cell proliferation and drive T cells toward Th1 and Tc1 polarization; however, HspB-pulseed HM DCs are unable to do so.
Mice immunized with bone marrow-derived dendritic cells stimulated with recombinant Coxiella burnetii Com1 and Mip demonstrate enhanced bacterial clearance in association with a Th1 immune response.
TLDR
The results demonstrate that Com1 and Mip are protective antigens and strongly indicate that they favor to induce IFN-γ-producing Th1 and Tc1 cells, whereas the non-protective antigen GroEL is biased to induce a Th2 response.
Coxiella burnetii antigen-stimulated dendritic cells mediated protection against Coxiella burnetii in BALB/c mice.
TLDR
It is suggested that PIIAg is far superior to PIAg in activating BMDCs to confer protection against C. burnetii in vivo, whereas Com1 and SecB are protective antigens because Com1- or SecB-pulsed BM DCs confer partial protection.
Identification of Coxiella burnetii CD8+ T-Cell Epitopes and Delivery by Attenuated Listeria monocytogenes as a Vaccine Vector in a C57BL/6 Mouse Model
TLDR
Data suggested that T4SS effectors represent an important class of C. burnetii antigens that can induce CD8+ T-cell responses and showed that attenuated L. monocytogenes vaccine vectors are an efficient antigen-delivery platform that can be used to induce robust protective CD8-cell immune responses against C. burningetii infection.
Serological characterization of surface-exposed proteins of Coxiella burnetii.
TLDR
The results suggest that these seroreactive SEPs have potential as serodiagnostic antigens or as subunit vaccine antIGens against Q fever, and the majority reacted with at least 50 % of the sera from mice infected with Cox.
Protein array of Coxiella burnetii probed with Q fever sera
TLDR
Results suggest that HspB had the highest fluorescence intensity value and positive frequency of all the proteins on the array when probed with both Q fever patient sera and mouse sera, and are potential serodiagnostic and subunit vaccine antigens of Q fever.
Identification of Novel Surface-Exposed Proteins of Rickettsia rickettsii by Affinity Purification and Proteomics
TLDR
5 novel SEPs identified herein might be involved in the interaction of R. rickettsii with vascular endothelial cells, and all of them except TolC were protective antigens.
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