Xiaolu Meng

Learn More
GABA (gamma-aminobutyric acid) receptor modulators have been investigated as a potential treatment strategy in Alzheimer's disease (AD). In the present study, we found that GABA levels were different in wild type (WT) and AβPP/PS1 mouse brains. GABA downregulated amyloid-β (Aβ) uptake in neurons through the receptor for advanced glycation end-products.(More)
Tree shrews, a species phylogenetically close to primates, are regarded as a suitable and naturalistic animal model for depression studies. However, psychological symptoms that are essential for depression diagnosis and treatment, such as helplessness and social withdrawal, have not been studied in this model. Therefore, in this study, we first investigated(More)
Dopaminergic activity in the nucleus accumbens (NAc) and the globus pallidus (GP) is important for the interaction between depression and addiction, with D1- and D2-like receptors playing different roles. Here, we address the effect of depression on morphine reward and its underlying D1- and D2-like effects in the NAc and/or the GP. Novelty-seeking(More)
  • 1