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This paper reviews recent important results in the development of neuromorphic network architectures (‘CrossNets’) for future hybrid semiconductor=nanodevice-integrated circuits. In particular, we have shown that despite the hardware-imposed limitations, a simple weight import procedure allows the CrossNets using simple two-terminal nanodevices to perform(More)
Hybrid semiconductor/molecular (“CMOL”) circuits may be used for hardware implementation of artificial neural network. Our studies show that such networks (“CrossNets”) may eventually exceed the mammal brain in areal density, at much higher speed and acceptable power consumption. In this report, we demonstrate that CrossNets based on simple (two-terminal)(More)
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with a 5-year survival rate less than 15%. Understanding of the molecular mechanisms involved in the pathogenesis of ESCC becomes critical to develop more effective treatments. Mcl-1 expression was measured by reverse transcription (RT)-PCR and Western blotting. Human Mcl-1(More)
This study aimed to investigate the effects of polysaccharide from Angelica and Astragalus (AAP) on carbon tetrachloride (CCl4) induced liver damage in mice. A total of 120 Kunming mice were randomly distributed among 6 groups comprising (i) the normal control mice, (ii) the CCl4 treatment group, (iii) the bifendate treatment group, (iv) the AAP treatment(More)
Although Akt is reported to play a role in morphine’s cardioprotection, little is known about the mechanism underlying morphine-induced Akt activation. This study aimed to define the molecular mechanism underlying morphine-induced Akt activation and to determine if the mechanism contributes to the protective effect of morphine on ischemia/reperfusion(More)
The major objective of the present study is to change the alanine production of Lactic acid bacteria by expression of Bacillus subtilis (natto) alanine dehydrogenase (AlaDH), the gene that is not present in Lactic acid. B. subtilis AlaDH gene (ald) was cloned into a pGEX6p-1 and expressed in E. coli JM109. Its enzyme activity was 48.3U/mg at 30 degrees C(More)
In this letter, we have found a more general formulation of the REward Increment = Nonnegative Factor times Offset Reinforcement times Characteristic Eligibility (REINFORCE) learning principle first suggested by Williams. The new formulation has enabled us to apply the principle to global reinforcement learning in networks with various sources of(More)
Hybrid “CMOL” integrated circuits, combining CMOS subsystem with nanowire crossbars and simple two-terminal nanodevices, promise to extend the exponential Moore-Law development of microelectronics into the sub-10-nm range. We are developing neuromorphic network (“CrossNet”) architectures for this future technology, in which neural cell bodies are(More)
We synthesized a novel magnetic composite, Fe3O4/Cu(Ni)Cr-LDH, as a heterogeneous catalyst for the degradation of organic dyes in the solution using sulfate radical-based advanced oxidation processes. The physicochemical properties of the composite synthesized via two-step microwave hydrothermal method were characterized by several techniques, such as X-ray(More)