Xiaoling Peng

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A microfluidic device combined with the microwell array and optical tweezers was set up for cell manipulation, localization and cultivation. Yeast cells were manipulated by a 1,064 nm laser and transferred to microwell array as a demonstration. The flow velocities at which the yeast cell can be confined in microwells of different sizes are characterized.(More)
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose(More)
Cell-substrate interaction is implicated in many physiological processes. Dynamical monitoring of cellular tractions on substrate is critical in investigating a variety of cell functions such as contraction, migration, and invasion. On account of the inherent ill-posed property as an inverse problem, cellular traction recovery is essentially sensitive to(More)
Experimental investigations have demonstrated that cells can actively sense and respond to physical aspects of their environments, such as substrate stiffness of biomaterials, via integrin receptors with the help of stochastic thermal undulations of cell membranes. This paper develops a physical model for the mechanism of integrin-dependent cell-substrate(More)
Cell adhesions are modulated by the interactions between cells and their surroundings, among which substrate stiffness plays an important role in mediating cellular behaviors and functions. Little is known, however, about the inherent mechanism of how nascent adhesion nucleation, as the precursor of focal adhesions, is regulated by substrate stiffness. This(More)
Quantitative estimation of cellular traction has significant physiological and clinical implications. As an inverse problem, traction force recovery is essentially susceptible to noise in the measured displacement data. For traditional procedure of Fourier transform traction cytometry (FTTC), noise amplification is accompanied in the force reconstruction(More)
Cell interactions with extracellular matrix, such as cell adhesion and spreading, are crucial for many biological functions and processes. Recent experimental progresses have demonstrated that substrate rigidities exert a remarkable influence on cell-substrate interfacial adhesion and spreading behaviors. The underlying biophysical mechanism, however,(More)
In this study, α-Fe2O3 nanowires were synthesized using mesoporous SBA-15 silica as the hard templates with the nanocasting method, and then mesoporous α-Fe2O3 nanowire bundles (NWBs) were separated from the well-dispersed α-Fe2O3 nanowires (NWs) by the centrifugation technique. Both samples were characterized by x-ray diffraction, transmission electron(More)
A simple magnetic force-based cell patterning method using soft lithogra-Cell patterning is gaining more and more attention regarding a wide range of applications including cell biology, tissue engineering, and biosensor technology, to name a few. Magnetic force provides a promising tool to pattern cells because it is of excellent biocompatibility, tunable(More)
In the present study, graphene/Fe3O4 nanocomposites were prepared by solvothermal method using graphite oxide (GO) and FeCl3 x 6H2O as starting materials and the products were characterized by X-ray Diffraction (XRD), Scanning Electronic Microscope (SEM) and Vibrating Sample Magnetometer (VSM). Effects of Fe ion concentration, temperature and time of(More)
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