Xiaolin Zong

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1. The kinetics of glycine-sensitive, N-methyl-D-aspartate (NMDA) receptor desensitization were investigated in cultured neurones with the patch clamp technique. 2. The degree of fast NMDA-receptor desensitization was inversely related to glycine concentration. Thus, increasing concentrations of glycine from 30 nM to 2.5 microM potentiated desensitized NMDA(More)
This paper presents a novel biomimetic olfactory biosensor for the study of olfactory transduction mechanisms on the basis of light addressable potentiometric sensor (LAPS), in which rat olfactory sensory neurons (OSNs) are used as sensing elements. Rat OSNs are cultured on the surface of LAPS chip. To validate the origin of the electrical signals recorded(More)
G protein-mediated downregulation of current through neuronal voltage-gated Ca2+ channels is well known. We now report that G protein activation by GTP gamma S increases the Ba2+ conductance of high-voltage-activated Ca2+ channels of chick dorsal root ganglion (DRG) cells. This occurs with a delay of minutes during which the channels are inhibited by the(More)
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