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We discuss numerical modeling attacks on several proposed strong physical unclonable functions (PUFs). Given a set of challenge-response pairs (CRPs) of a Strong PUF, the goal of our attacks is to construct a computer algorithm which behaves indistinguishably from the original PUF on almost all CRPs. If successful, this algorithm can subsequently(More)
We discuss the question of how physical statements can be proven over digital communication channels between two parties (a "prover" and a "verifier") residing in two separate local systems. Examples include: (i) "a certain object in the prover's system has temperature X°C", (ii) "two certain objects in the prover's system are positioned at distance(More)
One part of the original PUF promise was their improved resilience against physical attack methods, such as cloning, invasive techniques, and arguably also side channels. In recent years, however, a number of effective physical attacks on PUFs have been developed [17,18,20,8,2]. This paper continues this line of research, and introduces the first power and(More)
A highly reproducible and robust cell-based high-throughput screening (HTS) assay was adapted for screening of small molecules for antiviral activity against influenza virus strain A/Vietnam/1203/2004 (H5N1). The NIH Molecular Libraries Small Molecule Repository (MLSMR) Molecular Libraries Screening Centers Network (MLSCN) 100,000-compound library was(More)
The nucleocapsid (N) protein of hantavirus encapsidates viral genomic and antigenomic RNAs. Previously, deletion mapping identified a central, conserved region (amino acids 175 to 217) within the Hantaan virus (HTNV) N protein that interacts with a high affinity with these viral RNAs (vRNAs). To further define the boundaries of the RNA binding domain (RBD),(More)
BACKGROUND Inflammatory and immune responses triggered by brain ischemia worsen clinical outcomes of stroke and contribute to hemorrhagic transformation, massive edema, and reperfusion injury associated with intravenous alteplase. We assessed whether a combination of the immune-modulator fingolimod and alteplase is safe and effective in attenuating(More)
Extracted from the traditional Chinese medicine of Kushen, matrine is an alkaloid with potential anti-neoplastic and anti-inflammatory effects. Here, we examined the effect of matrine on proliferation and apoptosis of cultured retinoblastoma cells. The retinoblastoma cell lines Y79, WERI-RB1 and SO-RB50 were treated with matrine in increasing concentrations(More)
Physical Unclonable Functions (PUFs) use random physical variations to map input challenges to output responses in a way that is unique to each chip. PUFs are promising low cost security primitives but unreliability of outputs limits the practical applications of PUFs. This work addresses two causes of unreliability: environmental noise and device aging. To(More)
To examine a potential correlation between a thin cornea, a thin lamina cribrosa and a thin peripapillary sclera in normal eyes of Chinese, as surrogate for a presumed association between a thin cornea and an increased glaucoma susceptibility. The histomorphometric study included 55 non-glaucomatous globes (55 patients; mean age: 41.6 ± 13.6 years)(More)