Xiaoli Gong

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Parkinson's disease (PD) is an aging-associated neurodegenerative disorder with progressive pathology involving the loss of midbrain dopaminergic neurons. Neurotrophic factors are promising for PD gene therapy; they are integrally involved in the development of the nigrostriatal system. Cerebral dopamine neurotrophic factor (CDNF) was recently discovered to(More)
The complex pathogenesis of Alzheimer's disease (AD) involves multiple contributing factors, including amyloid β (Aβ) peptide accumulation, inflammation and oxidative stress. Effective therapeutic strategies for AD are still urgently needed. Triptolide is the major active compound extracted from Tripterygium wilfordii Hook.f., a traditional Chinese(More)
Prior evidence shows that acupuncture improves symptoms in both Parkinson's disease (PD) patients and animal models. We examined the effects of high-frequency (100 Hz) electroacupuncture (EA) on behavior in a rat PD model induced by medial forebrain bundle (MFB) transection. Neurotransmitters levels in the striatum were measured using in vivo microdialysis(More)
Recently, distribution is required in many DRM systems. However current distribution mechanisms appear to use restriction for distribution. In this paper, we propose a distribution mechanism based on using different licenses for different distributions. Particularly, we focus on taking interference to replace restriction and using degressive secret keys(More)
Microglia are key players for the inflammatory responses in the central nervous system. Suppression of microglial activation and the resulting production of proinflammatory molecules are considered a promising strategy to alleviate the progression of neurodegenerative disorders. Triptolide was demonstrated as a potent anti-inflammatory compound both in(More)
The acupuncture or electroacupuncture (EA) shows the therapeutic effect on various neurodegenerative diseases. This effect was thought to be partially achieved by its ability to alleviate existing neuroinflammation and glial dysfunction. In this study, we systematically investigated the effect of EA on abnormal neurochemical changes and motor symptoms in a(More)
Embedded systems are becoming ubiquitous and taking more and more important part in our daily life. Increasingly complex functionality leads to higher develop cost and lower software quality. Model checking has the potential of alleviating these problems. In this paper, we present an approach to construct model directly from the source code. An embedded(More)
This paper presents a DRM for Service Provider to reorganize resource from different DRMs, in view of the present situation of Chinese digital publishing industry. This DRM helps SP to provide value-added service which could be quite different from CP providing, such as redistribution, recommendation, renting and so on. It repackages various DRM licenses(More)
HBase distributed database technology has been widely used in missive data processing. The problem of the efficiency of multi-dimensional data query which is caused by its single primary key indexing becomes more apparent. This paper proposed and implemented a multi-dimensional query method based on Hilbert space-filling curve. Using the Hilbert space(More)