Xiaoli Cui

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Deoxycytidine kinase (dCK) is a rate limiting enzyme critical for phosphorylation of endogenous deoxynucleosides for DNA synthesis and exogenous nucleoside analogues for anticancer and antiviral drug actions. dCK is activated in response to DNA damage; however, how it functions in the DNA damage response is largely unknown. Here, we report that dCK is(More)
Clustering analysis is one of the most commonly used data processing algorithms. Over half a century, K-means remains the most popular clustering algorithm because of its simplicity. Recently, as data volume continues to rise, some researchers turn to MapReduce to get high performance. However, MapReduce is unsuitable for iterated algorithms owing to(More)
Phage therapy requires the comprehensive understanding of the mechanisms underlying the host-phage interactions. In this work, to identify the genes related to Pseudomonas aeruginosa phage K8 receptor synthesis, 16 phage-resistant mutants were selected from a Tn5G transposon mutant library of strain PAK. The disrupted genetic loci were identified and they(More)
The catecholaminergic neurotoxin 6-hydroxydopamine has been widely used to mimic the lesions in dopaminergic neurons to develop Parkinson’s disease. The present study was aimed to evaluate the combined treatment with Curcumin and desferrioxamine (DFO) on 6-OHDA- induced neurotoxicity in the striatum of rats. Rat models with 6-OHDA-induced Parkinson’s(More)
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