Xiaolei Song

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Biocompatible nanomaterials and hydrogels have become an important tool for improving cell-based therapies by promoting cell survival and protecting cell transplants from immune rejection. Although their potential benefit has been widely evaluated, at present it is not possible to determine, in vivo, if and how long cells remain viable following their(More)
Chemical exchange saturation transfer (CEST) has emerged as a novel MRI contrast mechanism that is well suited for molecular imaging studies. This new mechanism can be used to detect small amounts of contrast agent through the saturation of rapidly exchanging protons on these agents, allowing a wide range of applications. CEST technology has a number of(More)
Three experiments were conducted to determine whether an object-based correspondence effect for torch (flashlight) stimuli reported by Pellicano et al. [( 2010 ). Simon-like and functional affordance effects with tools: The effects of object perceptual discrimination and object action state. Quarterly Journal of Experimental Psychology, 63, 2190-2201] is(More)
Based on an independent forward model in fluorescent tomography, a parallel reconstructed scheme for inhomogeneous mediums with unknown absorption property is proposed in this paper. The method considers the two diffusion equations as separately describing the propagation of excited light in tissues with and without fluorescent probes inside. Then the(More)
Alterations in mucin expression and glycosylation are associated with cancer development. Underglycosylated mucin-1 (uMUC1) is overexpressed in most malignant adenocarcinomas of epithelial origin (for example, colon, breast and ovarian cancer). Its counterpart MUC1 is a large polymer rich in glycans containing multiple exchangeable OH protons, which is(More)
Chemical exchange saturation transfer MRI is a promising new technique for cellular and molecular imaging. This contrast allows the detection of tumors and ischemia without the use of gadolinium as well as the design of microenvironment-sensitive probes that can be discriminated based on their exchange contrast properties and saturation frequency. Current(More)
Fluorescence molecular tomography in the near-infrared region is becoming a powerful modality for mapping the three-dimensional quantitative distributions of fluorochromes in live small animals. However, wider application of fluorescence molecular tomography still requires more accurate and stable reconstruction tools. We propose a shape-based(More)
The application of CCD camera improves the quality of fluorescence molecular tomography (FMT). However, large size of data set offered by CCD might increase the computational burden in the reconstruction. To balance the data size and reconstruction quality, singular value decomposition (SVD)-based analysis is applied. Simulation is performed with mouse(More)
Conjugate gradient method is verified to be efficient for nonlinear optimization problems of large-dimension data. In this paper, a penalized linear and nonlinear combined conjugate gradient method for the reconstruction of fluorescence molecular tomography (FMT) is presented. The algorithm combines the linear conjugate gradient method and the nonlinear(More)
Internal migrants are the individuals who migrate between regions in one country. The number of internal migrants were estimated at 245 million in China in 2013. Results were inconsistent in the literature about the relationship between their health statuses and social integration. The main difference exists on how to measure the social integration and(More)