Xiaolei Jiang

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The E2F1 transcription factor regulates cell proliferation and apoptosis through the control of a considerable variety of target genes. Previous work has detailed the role of other transcription factors in mediating the specificity of E2F function. Here we identify the NF-YB transcription factor as a novel direct E2F1 target. Genome-wide expression analysis(More)
To construct the recombinant vector Pact-EGFP, the Act-1 core promoter region was amplified from the pUCm-T/Act-1 and subcloned into pEGFP-4.1 vector (derived from pEGFP-N1 with the removal of human cytomegalovirus immediate early promoter), by restriction enzymes Bgl II and Hind III. Transfection of Pact-EGFP vector into Vero cell by liposome indicated(More)
The extracted toxic barley protein showed different protein content depending on the barley strain and demonstrated an inhibitory effect on the growth of yeast and glucose consumption. Chinese barley Danpi-2 had the highest concentration of toxic protein of all the types barley tested. When the concentration of proteins was increased to 32 μg/ml, the(More)
Human aggressive B-cell non-Hodgkin lymphomas (NHL) encompass the continuum between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL), and display considerable clinical and biologic heterogeneity, most notably related to therapy response. We previously showed that lymphomas arising in the Eμ-Myc transgenic mouse are heterogeneous, mirroring genomic(More)
Affiliations: 1 Duke Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina, USA 2 Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, USA 3 Cancer Science Institute of Singapore, National University of Singapore, Singapore 4 The Cancer Institute, Japanese Foundation of Cancer(More)
Human aggressive B-cell non-Hodgkin lymphomas (NHL) encompass the continuum between Burkitt lymphoma and diffuse large B-cell lymphoma (DLBCL), and display considerable clinical and biologic heterogeneity, most notably related to therapy response. We previously showed that lymphomas arising in the Em-Myc transgenic mouse are heterogeneous, mirroring genomic(More)
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