Xiaolan Jiang

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Intrahepatic cholangiocarcinoma (ICC) is a fatal primary liver cancer (PLC) that affects 5-10% of all PLCs. Here we sequence tumour and matching control sample pairs of a large cohort of 103 ICC patients in China, resulting in the identification of an ICC-specific somatic mutational signature that is associated with liver inflammation, fibrosis and(More)
Flavonoid 3′,5′-hydroxylase (F3′5′H), an important branch point enzyme in tea plant flavan-3-ol synthesis, belongs to the CYP75A subfamily and catalyzes the conversion of flavones, flavanones, dihydroflavonols and flavonols into 3′,4′,5′-hydroxylated derivatives. However, whether B-ring hydroxylation occurs at the level of flavanones and/or(More)
Phenolic compounds in tea plant [Camellia sinensis (L.)] play a crucial role in dominating tea flavor and possess a number of key pharmacological benefits on human health. The present research aimed to study the profile of tissue-specific, development-dependent accumulation pattern of phenolic compounds in tea plant. A total of 50 phenolic compounds were(More)
BACKGROUND There is no information available about occult hepatitis B virus (HBV) infection (OBI) in individuals with intrahepatic cholangiocarcinoma (ICC). GOALS To investigate the correlation between OBI and ICC. STUDY A retrospective case-control study was conducted. The cases were 183 cryptogenic ICC patients (group I), and the controls were 549(More)
This paper studies the user-behavior driven CCN caching jointly investigating the video popularity and video drop ratio. As far as the authors understand, this is the rst paper taking the video drop ratio into consideration in CCN caching scheme design. The preliminary simulation results show that the proposed caching scheme can achieve better performances(More)
The flashover performance of insulators is significantly affected by the degrees and ways of wetting the pollution layer. However, there have only been a few reports on the wetting condition and its effects on the flashover characteristics of pollution on insulators to date. In this paper, a phase-angle difference-based method is proposed to test the(More)
Anthocyanidin reductase (ANR) is a key enzyme in the ANR biosynthetic pathway of flavan-3-ols and proanthocyanidins (PAs) in plants. Herein, we report characterization of the ANR pathway of flavan-3-ols in Shuchazao tea (Camellia sinesis), which is an elite and widely grown cultivar in China and is rich in flavan-3-ols providing with high nutritional value(More)
Light is an important source of energy as well as environmental signal for the regulation of biosynthesis and accumulation of multiple secondary metabolites in plants. Polyphenols are the major class of secondary metabolites in tea, which possess potential antioxidant properties. In order to investigate the effect of light signal on the regulation of(More)
Tea (Camellia sinensis) is rich in flavan-3-ols (catechins), especially epicatechin (EC), which is the predominant extension unit of polymeric proanthocyanidins (PAs). However, studies assessing EC's stereochemistry are scarce. Here, a high performance liquid chromatography column using amylose tris-(3, 5-dimethylphenylcarbamate) immobilized on silica-gel(More)
For in-service transmission lines, insulator icing condition depends on analysis of images collected by cameras installed on towers, and ice type analysis is mostly completed by human beings, which is infeasible to monitor a large area. Although image processing is successfully applied to segmentation of insulators from aerial images, there are few(More)