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Regulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo-electron microscopy at 3.5-Å resolution reveals that in the mature virus at neutral extracellular pH, the N-terminal 20-amino-acid segment of M (involving three pH-sensing histidines) latches and(More)
BACKGROUND Human exposure to silica dust is very common in both working and living environments. However, the potential long-term health effects have not been well established across different exposure situations. METHODS AND FINDINGS We studied 74,040 workers who worked at 29 metal mines and pottery factories in China for 1 y or more between January 1,(More)
This study presents a novel approach for unsupervised change detection in multitemporal remotely sensed images. This method addresses the problem of the analysis of the difference image by proposing a novel and robust semi-supervised fuzzy C-means (RSFCM) clustering algorithm. The advantage of the RSFCM is to further introduce the pseudolabels from the(More)
Validation of land cover products is a fundamental task prior to data applications. Current validation schemes and methods are, however, suited only for assessing classification accuracy and disregard the reliability of land cover products. The reliability evaluation of land cover products should be undertaken to provide reliable land cover information. In(More)
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